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Major Advance In Treatment Of Multiple Myeloma

Date:
April 7, 2007
Source:
Mayo Clinic
Summary:
Mayo Clinic Cancer Center announced that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone.

Mayo Clinic Cancer Center announced that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone.

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The study led by the Eastern Cooperative Oncology Group (ECOG) and supported by the National Cancer Institute compared combination treatment of oral medications lenalidomide and either high- or low-dose dexamethasone in 445 patients with newly-diagnosed myeloma. Lenalidomide plus high-dose dexamethasone had a one-year survival rate of 86 percent. The comparative therapy using low-dose dexamethasone showed a significantly higher 96.5 percent overall survival rate at one year, with much less toxicity.

"In my opinion, this is the best one-year survival data that I've seen in a large phase 3 study in myeloma," says Vincent Rajkumar, M.D., Mayo Clinic hematologist and primary investigator of the ECOG study. "This is a major advance in the treatment of this cancer."

All patients on the high-dose dexamethasone arm of the clinical trial will be moved to the low-dose arm. A successor study using lenalidomide plus high-dose dexamethasone was closed early as a result of these findings.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Major Advance In Treatment Of Multiple Myeloma." ScienceDaily. ScienceDaily, 7 April 2007. <www.sciencedaily.com/releases/2007/04/070404174310.htm>.
Mayo Clinic. (2007, April 7). Major Advance In Treatment Of Multiple Myeloma. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/04/070404174310.htm
Mayo Clinic. "Major Advance In Treatment Of Multiple Myeloma." ScienceDaily. www.sciencedaily.com/releases/2007/04/070404174310.htm (accessed November 26, 2014).

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