Featured Research

from universities, journals, and other organizations

Dopamine-related Drugs Affect Reward-seeking Behavior

Date:
April 30, 2007
Source:
American Academy of Neurology
Summary:
Drugs that adjust dopamine levels in the brain greatly affect how people react to success and failure, according to a new study.

Drugs that adjust dopamine levels in the brain greatly affect how people react to success and failure, according to research presented at the American Academy of Neurology's 59th Annual Meeting in Boston.

Related Articles


In a first-of-its-kind study on humans, researchers measured how dopamine-related drugs affect the striatum, a part of the brain that is stimulated by rewards. The study, conducted at the Wellcome Trust Centre for Neuroimaging in London, involved 39 healthy people between the ages of 18 and 39. Participants were divided into three groups. One group was given levodopa, a drug that increases dopamine levels in the brain. Another took haloperidol, a dopamine receptor blocker. The third was given a placebo. Dopamine is a chemical naturally produced by the body that transmits signals between nerve cells.

Researchers showed each group symbols associated with winning or losing different amounts of money. To "win" more money, participants had to learn through trial and error which symbols resulted in which outcomes.

The study found people who took levodopa were 95 percent more likely to choose symbols associated with higher monetary gains than those who took haloperidol. As a result, the levodopa group won more money, but they did not lose less money.

"The results show dopamine drives us to get what we want, but not avoid what we fear," said study author Mathias Pessiglione, PhD, who now works at the Salpetriere Hospital in Paris, France.

The findings may provide a better understanding of the side effects of dopamine-related drugs and the disorders they are used to treat, such as Parkinson's disease and schizophrenia. "This study may explain why dopamine depletion leads to the lack of motivation often described in people with Parkinson's disease," said Pessiglione, "and how dopamine replacement therapy can cause compulsive behaviors, such as overeating and gambling addictions, in the same people."


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Dopamine-related Drugs Affect Reward-seeking Behavior." ScienceDaily. ScienceDaily, 30 April 2007. <www.sciencedaily.com/releases/2007/04/070427072318.htm>.
American Academy of Neurology. (2007, April 30). Dopamine-related Drugs Affect Reward-seeking Behavior. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2007/04/070427072318.htm
American Academy of Neurology. "Dopamine-related Drugs Affect Reward-seeking Behavior." ScienceDaily. www.sciencedaily.com/releases/2007/04/070427072318.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Reuters - Innovations Video Online (Mar. 25, 2015) European researchers say our smartphone use offers scientists an ideal testing ground for human brain plasticity. Dr Ako Ghosh&apos;s team discovered that the brains and thumbs of smartphone users interact differently from those who use old-fashioned handsets. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Many Don't Know They Have Alzheimer's, But Their Doctors Do

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors. Video provided by Newsy
Powered by NewsLook.com
A Quick 45-Minute Nap Can Improve Your Memory

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins