Featured Research

from universities, journals, and other organizations

Liver Stiffness Indicates Portal Hypertension

Date:
May 4, 2007
Source:
John Wiley & Sons, Inc.
Summary:
Measuring liver stiffness using transient elastography can predict severe portal hypertension in patients with hepatitis C-related cirrhosis.

Measuring liver stiffness using transient elastography can predict severe portal hypertension in patients with hepatitis C-related cirrhosis, according to a new study in the May issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases.

Related Articles


As liver disease progresses, fibrosis leads to portal hypertension which causes potentially lethal complications such as variceal hemorrhage, ascites and portosystemic encephalopathy. Measuring the hepatic venous pressure gradient (HVPG) is the standard method used to assess portal pressure and predict its complications; however, the procedure is invasive, expensive, and requires technical expertise.

In search of another way to assess liver fibrosis and portal hypertension, researchers, led by Massimo Pinzani, MD, PhD, of the University of Florence, sought to evaluate transient elastography, a rapid, non-invasive technique to measure liver stiffness. They compared its accuracy in detecting portal hypertension and its complications with that of HVPG measurement.

Between March 1, 2005 and July 1, 2006, the researchers studied 61 consecutive patients with diagnosed or suspected cirrhosis from chronic HCV infection. Each patient underwent transient elastography to measure liver stiffness. Immediately afterward, they underwent HVPG measurement and liver biopsy. The researchers then analyzed the data and compared the diagnostic tools.

"Considering the whole patient population, a statistically significant, positive correlation between HVPG and liver stiffness measurement was found," they report. The correlation was excellent for HVPG values less than 10 or 12 mmHg, but not as good for greater HVPG values. They also noted a correlation between liver stiffness measurement and the presence of esophageal varices, however, the negative and positive predictive values for the detection of varices were unsatisfactory, at 66 percent and 77 percent respectively.

"We suggest that measurement of liver stiffness by transient elastography may represent a reliable non-invasive methodology for the prediction of clinically significant and severe portal hypertension, although not good enough to replace endoscopy for the detection of varices," the authors conclude.

Article: "Liver Stiffness Measurement Predicts Severe Portal Hypertension in Patients with HCV-Related Cirrhosis" Vizzutti, Francesco; Arena, Umberto; Romanelli, Roberto; Rega, Luigi; Foschi, Marco; Colagrande, Stefano; Petrarca, Antonio; Moscarella, Stefania; Belli, Giacomo; Zignego, Anna Linda; Marra, Fabio; Laffi, Giacomo; Pinzani, Massimo Hepatology; May 2007; (DOI: 10.1002/hep.21665).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Liver Stiffness Indicates Portal Hypertension." ScienceDaily. ScienceDaily, 4 May 2007. <www.sciencedaily.com/releases/2007/05/070501115045.htm>.
John Wiley & Sons, Inc.. (2007, May 4). Liver Stiffness Indicates Portal Hypertension. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2007/05/070501115045.htm
John Wiley & Sons, Inc.. "Liver Stiffness Indicates Portal Hypertension." ScienceDaily. www.sciencedaily.com/releases/2007/05/070501115045.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins