Featured Research

from universities, journals, and other organizations

No Evidence Older Women Generate New Eggs

Date:
May 9, 2007
Source:
University of South Florida Health
Summary:
It is highly unlikely that older women generate new eggs, report researchers at the University of South Florida in collaboration with a center in China.

Dr. David Keefe and Dr. Lin Liu.
Credit: Image courtesy of University of South Florida Health

It is highly unlikely that older women generate new eggs, report researchers at the University of South Florida in collaboration with a center in China.

The USF study, published in the March 2007 issue of the journal Developmental Biology and highlighted April 26, 2007 in Nature, counters the controversial findings of reproductive endocrinologist Jonathan Tilly, PhD, and his team of Harvard scientists.

Tilly’s work, published in 2004 in Nature with a follow-up study a year later in Cell, challenged the biological dogma that mammals, including women, are born with a limited lifetime supply of eggs. Tilly reported the discovery of stem cells capable of migrating from bone marrow to mouse ovaries and generating new eggs there. The research fueled hopes that a new treatment – such as bone marrow transplantation – might one day help older women regain their fertility.

Since then, other papers have refuted Tilly’s surprising finding that mice can produce eggs throughout their lives. Now, David Keefe, MD, professor and chair of Obstetrics and Gynecology at USF, and colleague Lin Liu, who also holds a post at Sun Yat-Sen University in Guangzhou, China, say they can find no evidence to support his hypothesis that women may generate new eggs after birth.

The USF researchers searched for markers of stem cells or of meiotic cell division in ovarian cells biopsied from 12 women between the ages of 28 and 53.

“Despite using the most sensitive methods available, we found no evidence of any egg stem cells in human ovaries, demonstrating that Dr. Tilly’s findings in mice do not apply to women,” Dr. Keefe said. “Dr. Tilly likely was seeing non-egg cells which resemble eggs. Another reason his findings do not apply to women could be because mice eggs are more resilient than women’s eggs. The bottom line is that women should not expect stem cell therapy to treat egg infertility or menopause in the foreseeable future.”

“This is a very important finding by a distinguished group of researchers and clinician-scientists at USF Health which affirms the traditional dogma of a finite period of fertility in women,” said Abdul S. Rao, MD, MA, DPhil, senior associate vice president for USF Health and vice dean for research and graduate affairs at the College of Medicine.

The traditional view of fertility holds that women are born with all their eggs and they are released one by one (occasionally two) at each ovulation. At menopause, few to no mature eggs are believed to remain in the ovaries.


Story Source:

The above story is based on materials provided by University of South Florida Health. Note: Materials may be edited for content and length.


Cite This Page:

University of South Florida Health. "No Evidence Older Women Generate New Eggs." ScienceDaily. ScienceDaily, 9 May 2007. <www.sciencedaily.com/releases/2007/05/070508123631.htm>.
University of South Florida Health. (2007, May 9). No Evidence Older Women Generate New Eggs. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2007/05/070508123631.htm
University of South Florida Health. "No Evidence Older Women Generate New Eggs." ScienceDaily. www.sciencedaily.com/releases/2007/05/070508123631.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins