Featured Research

from universities, journals, and other organizations

Anti-inflammatory Drugs Interact With Hormone Replacement Therapy, And More

Date:
May 24, 2007
Source:
Public Library of Science
Summary:
Any cardio protective effect of hormone replacement therapy may be inhibited if women are taking a particular type of non-steroidal anti-inflammatory pain killer, according to new research.

Any cardio protective effect of hormone replacement therapy may be inhibited if women are taking a particular type of non-steroidal anti-inflammatory pain killer, report researchers led by Garret FitzGerald from University of Pennsylvania. The researchers examined the medical records of 1,673 women aged between 50 and 84 years from the UK's General Practice Research Database who had heart attacks or who died from coronary heart disease and compared them with 7,005 control women.

Current use of hormone replacement therapy was associated with a significantly lower risk of heart attack than non-use; with an odds ratio of 0.78. However, in women who used traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, which variably inhibit both cyclooxygenase (COX)-1 and COX-2, at the same time as hormone replacement therapy, the chance of heart attack among this group o f women, as compared to nonusers of these NSAIDs and hormone replacement therapy, was 1.5, which was not significantly different.

There is conflicting evidence from previous work about whether hormone replacement therapy protects against heart disease in women. In addition, any beneficial effect of hormone replacement therapy on the heart might be counteracted by NSAIDs which inhibit COX-2. Inhibition of COX-2 prevents production of prostacyclin, which has a role in preventing blood clotting. As estrogen acts to increase production of prostacyclin; it is possible that the effect of hormone replacement therapy on the heart is counteracted by these NSAIDs.

The authors conclude that "these observations, based on small numbers, are provocative rather than conclusive and are not intended to guide clinical practice, but rather to prompt additional research." Ultimately determination of the clinical implications of these findings will need to be addressed in future trials.

Citation: Garcia Rodr1guez LA, Egan K, FitzGerald GA (2007) Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: A drug--drug interaction" PLoS Med 4(5): e157. doi:10.1371/journal.pmed.0040155 (http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040157)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Anti-inflammatory Drugs Interact With Hormone Replacement Therapy, And More." ScienceDaily. ScienceDaily, 24 May 2007. <www.sciencedaily.com/releases/2007/05/070521213010.htm>.
Public Library of Science. (2007, May 24). Anti-inflammatory Drugs Interact With Hormone Replacement Therapy, And More. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2007/05/070521213010.htm
Public Library of Science. "Anti-inflammatory Drugs Interact With Hormone Replacement Therapy, And More." ScienceDaily. www.sciencedaily.com/releases/2007/05/070521213010.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins