Featured Research

from universities, journals, and other organizations

How To Lose Weight And Not Go Hungry: Researcher Develops Drug That Mimics Feeling Of 'Fullness'

Date:
June 7, 2007
Source:
The Hebrew University of Jerusalem
Summary:
Millions of people the world over suffer today from obesity, yet there is no "magic bullet" that has yet provided a universally accepted solution. However, a young researcher at the Hebrew University of Jerusalem feels he has come up with a practical weight loss solution for the obese person without his having to feel hungry.

Yaniv Linde in his lab.
Credit: Hebrew University / Photo by Sasson Tiram

Millions of people the world over suffer today from obesity, yet there is no "magic bullet" that has yet provided a universally accepted solution. However, a young researcher at the Hebrew University of Jerusalem feels he has come up with a practical weight loss solution for the obese person without his having to feel hungry.

For this development, Yaniv Linde, a 32-year-old Ph.D. student of Prof. Chaim Gilon in the Department of Organic Chemistry at the Hebrew University, has been named a first place winner of a Kaye Innovation Award, which was presented today (June 6) during the 70th meeting of the Hebrew University Board of Governors.

Linde and his associates have developed a compound that mimics the activity of the naturally occurring hormone called aMSH. This hormone is naturally excreted during eating and binds to a receptor in the brain called MC4R. When this "communication" occurs on a substantial level, the brain sends out a signal that one feels "full."

The young Hebrew university researchers developed a novel method for synthesizing a peptide (a peptide is a compound linking two or more amino acids) which can serve as an analog to the naturally occurring aMSH hormone. They were able to demonstrate that their peptide, which they call BL-3020, displayed good metabolic stability to intestinal enzymes when swallowed, and that it was able to cross the intestinal wall and gain access into the blood stream. Once in the blood, it could make its way to the MC4R receptor and "close the circuit" to send out the "full" signal.

The result is that a person seriously wishing to overcome obesity could take this compound orally in order to curb his appetite, thus leading to natural weight loss. In experiments with mice, it was shown that a single oral administration of BL-3020 led to reduced consumption over a period of 24 hours. Over a 12-day period of daily dosages, the mice weighed 40 percent less than the average for mice of their size and age who were not being given the compound.

The peptide has been patented in Europe and the U.S., and a commercial firm, Bioline RX Ltd. of Jerusalem has purchased development rights from Yissum, the Hebrew University's technology transfer company, and is currently working towards creating a commercial anti-obesity drug.

The Kaye Innovation Awards at the Hebrew University have been awarded annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.


Story Source:

The above story is based on materials provided by The Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

The Hebrew University of Jerusalem. "How To Lose Weight And Not Go Hungry: Researcher Develops Drug That Mimics Feeling Of 'Fullness'." ScienceDaily. ScienceDaily, 7 June 2007. <www.sciencedaily.com/releases/2007/06/070606113405.htm>.
The Hebrew University of Jerusalem. (2007, June 7). How To Lose Weight And Not Go Hungry: Researcher Develops Drug That Mimics Feeling Of 'Fullness'. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2007/06/070606113405.htm
The Hebrew University of Jerusalem. "How To Lose Weight And Not Go Hungry: Researcher Develops Drug That Mimics Feeling Of 'Fullness'." ScienceDaily. www.sciencedaily.com/releases/2007/06/070606113405.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins