Featured Research

from universities, journals, and other organizations

Over One-third Of Refractory Lupus Patients Remain Stable After Receiving B-cell Depletion Therapy

Date:
June 19, 2007
Source:
European League Against Rheumatism
Summary:
Thirty-six percent of patients with refractory systemic lupus erythematosus remain well after undergoing B-cell depletion therapy without needing further standard immunosuppressive agents, according to a new study.

36% of patients with refractory systemic lupus erythematosus (SLE or lupus) remain well after undergoing B-cell depletion therapy (BCDT) without needing further standard immunosuppressive agents, according to a study presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

Overactive B-cells are commonly found in patients with SLE and reducing the number of B-cells in the system by BCDT has been suggested as a promising therapy for SLE patients who are unresponsive to other treatments.

In this study, initiated in 2000, patients with refractory SLE were treated with BCDT (based on rituximab) using a combination protocol with cyclophosphamide and steroids. Of the 33 patients who had a minimum of 6 months follow-up duration at the time of analysis (mean duration 37 months, range 6-79), 12 patients remained well.

Median duration of B-cell depletion was 4 months (range 2-15), with 2 patients remaining depleted at time of analysis (73 and 8 months respectively). B-cell depletion was beneficial clinically, with a decrease of median global BILAG scores (clinical activity index -- see Editors note) from 13 to 5 when measured between 5 and 8 months p<0.0001).

Autoantibody profiling was also examined during the study as a possible predictor of flare of disease. Patients with low baseline serum C3 (84%) had a shorter time to flare post-BCDT (a lower level is a strong indicator of high levels of disease activity) and patients with anti-ENA antibodies notably anti-Sm antibodies (63%) were more likely to flare at any time after BCDT with an odds ratio (OR) of 6 (p=0.03).

Co-author of the paper, Professor David Isenberg, from University College London in the United Kingdom, commented: "Although double blind trials are awaited, our results are encouraging. They show that B-cell depletion therapy is a promising therapeutic option for lupus patients who have a historically difficult to treat disease, and potentially could minimise the need for continuous immunosuppressive therapy. Through monitoring the autoantibody profile of these patients we have seen a strong association with disease activity post-BCDT, offering us valuable insight for future patient identification strategies."

Of the 20 patients who experienced flares after receiving BCDT, 11 flared between 6-12 months post-BCDT, with a mean time to flare (TTF) of 10 months post-BCDT. Thirteen patients have been retreated with at least another cycle of rituximab. In terms of B-cell depletion, one patient in the study sample did not deplete at all.

The study concludes that the long term safety profile of B-cell depletion therapy is so far favourable, though ongoing vigilance is recommended. Serious adverse events included reports of pneumococcal sepsis, severe serum sickness reaction and seizure related to hyponatriaemia. Two patient deaths occurred during the follow up assessment period.

About Lupus

Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. The course of the disease is unpredictable, with periods of illness (called flares) alternating with periods of inactivity (remission). SLE is found most commonly in women.

About BILAG

The BILAG index is a clinical measure of SLE disease activity. A flare of active SLE in this study was defined as a new BILAG A or two new BILAG B scores in any organ system. An increase in BILAG score represents an increase in symptom severity or worsening symptoms.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Over One-third Of Refractory Lupus Patients Remain Stable After Receiving B-cell Depletion Therapy." ScienceDaily. ScienceDaily, 19 June 2007. <www.sciencedaily.com/releases/2007/06/070614094846.htm>.
European League Against Rheumatism. (2007, June 19). Over One-third Of Refractory Lupus Patients Remain Stable After Receiving B-cell Depletion Therapy. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/06/070614094846.htm
European League Against Rheumatism. "Over One-third Of Refractory Lupus Patients Remain Stable After Receiving B-cell Depletion Therapy." ScienceDaily. www.sciencedaily.com/releases/2007/06/070614094846.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins