Featured Research

from universities, journals, and other organizations

Improvement Of Rheumatoid Arthritis Found During Pregnancy

Date:
June 15, 2007
Source:
European League Against Rheumatism
Summary:
Disease activity in patients with rheumatoid arthritis is significantly reduced during pregnancy, according to new data. In the study, RA improved significantly from the first trimester to the third trimester of the participants' pregnancy and this effect extended into the postpartum stage.

Disease activity in patients with rheumatoid arthritis (RA) is significantly reduced during pregnancy, according to new data.  In the study, RA improved significantly from the first trimester to the third trimester of the participants' pregnancy and this effect extended into the postpartum stage.

This is the first prospective study to confirm the relationship between RA and pregnancy, tracking 124 female RA patients throughout their pregnancy and at 6, 12 and 26 weeks postpartum. The RA improvement was seen in 40% of patients. Furthermore, 64% of patients remained relatively stable or improved postpartum. Only a third of patients (36%) experienced flares (periods of worsened symptoms), 5% severely.

Dr Yaël de Man of Erasmus MC University Medical Center, Rotterdam, The Netherlands, who performed this research, said: "Whilst previous literature has suggested an improvement of RA in pregnancy, this is the first prospective study to put a figure to this. The percentage of patients experiencing flares was much lower than previous studies, which we attribute to adequately-used DMARDs and biologicals to suppress disease activity postpartum. It is also interesting to note the existence of a complex interaction between female hormones during pregnancy and the epidemiology of RA, which may contribute to the development of new prevention and treatment approaches."

In the study, patients were assessed according to medication use, the Disease Activity Score DAS28 and the level of inflammation marker C-reactive protein (CRP). Disease activity was calculated with DAS28-CRP with 3 variables (DAS28-CRP-3). The change between the DAS28 at first and third trimester was used to categorise patients according to the EULAR response criteria into good, moderate and non-responders. The change between the DAS28 at 6 weeks and 12 or 26 weeks postpartum was used to determine if a severe or moderate flare was present.

The DAS28 decreased significantly during pregnancy from 3.7 (SD 1.1) in the first trimester to 3.4 (SD 1.1) in the third trimester (n=124, p=0.003). The mean DAS28 was 3.4 (SD 1.1) at six weeks postpartum. During pregnancy, 11% (49/124) were good responders, 40% were at least moderate responders (49/124) and 60% (75/124) were non-responders. The relapse of disease activity was present at twelve weeks postpartum with a mean DAS28 of 3.7 (SD 1.2) and was slightly lower at 26 weeks postpartum with a mean of 3.6 (SD 1.2). Postpartum, 5% (5/110) had a severe flare, 36% (40/110) had at least a moderate flare and 64% (70/110) remained relatively stable or improved.

During all trimesters, the percentages of DMARDs used were stable (sulfasalazine 32%, prednisone 35%, hydroxychloroquine 1% and gold i.m 1%), whilst DMARD use rose considerably postpartum (57% at the third trimester versus 82% post partum), mainly due to methotrexate (44%) and biologicals (8%).

This research was presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

This study was supported by the Dutch Arthritis Association.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Improvement Of Rheumatoid Arthritis Found During Pregnancy." ScienceDaily. ScienceDaily, 15 June 2007. <www.sciencedaily.com/releases/2007/06/070614154855.htm>.
European League Against Rheumatism. (2007, June 15). Improvement Of Rheumatoid Arthritis Found During Pregnancy. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2007/06/070614154855.htm
European League Against Rheumatism. "Improvement Of Rheumatoid Arthritis Found During Pregnancy." ScienceDaily. www.sciencedaily.com/releases/2007/06/070614154855.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins