Featured Research

from universities, journals, and other organizations

Hormone Therapy Offers New Hope For Ovarian Cancer Patients

Date:
June 17, 2007
Source:
University of Edinburgh
Summary:
Researchers have shown that the use of anti-estrogen drugs can extend life in ovarian cancer patients by up to three years. Hormone therapy can extend life in ovarian cancer patients, giving women a new alternative to chemotherapy.

Researchers at the University of Edinburgh have shown that hormone therapy can extend life in ovarian cancer patients, giving women a new alternative to chemotherapy.

Related Articles


The study, published in Clinical Cancer Research, has proved for the first time that the targeted use of an anti-estrogen drug could prolong the life of some patients by up to three years, and delay the use of chemotherapy in others.

Letrozole hormone therapy -- already used with great success in the treatment of breast tumours - attacks cancer by turning off its estrogen supply. But scientists now believe that in those ovarian cancers which are highly sensitive to estrogen, this blocking mechanism could slow the growth and spread of disease.

The study was funded by Cancer Research UK and involved 44 women with high estrogen receptor (ER) levels, whose cancer had relapsed after surgery and chemotherapy.

Scientists used a blood-borne tumour marker, CA-125, to track the progress of tumours during hormone treatment. They discovered that one quarter of the women showed no tumour growth after six months of anti-estrogen therapy, and 33 per cent of the group with the greatest ER values showed a positive response which delayed the use of chemotherapy.

John F. Smyth, Professor of Medical Oncology at the University of Edinburgh, led the research programme.

He said: "This is an important landmark in the research and treatment of ovarian cancer. Despite intense scientific research over the past 20 years, there have been few new leads in our understanding of how this disease operates. But this study suggests that the addition of hormone therapy to our treatment strategy could extend and improve the lives of women with cancer."

Ovarian cancer is the most commonly fatal of gynaecological cancers, affecting 1 in 48 women. Nearly 7,000 new cases are diagnosed in the UK each year.

Current treatment involves surgery and chemotherapy, but most ovarian cancers return within two years. Until now, further treatment options have been limited to a second course of chemotherapy, with serious implications for quality of life. It is hoped hormone treatment could offer life-extension with negligible side effects.

Dr Simon Langdon, senior lecturer in cancer research at the University of Edinburgh and the lead scientist behind this trial, said: "Ovarian cancer can be a devastating disease, so this new discovery is particularly exciting. We still have a lot to do, but this research has furthered our understanding of the hormone control of ovarian cancer, which could provide less grueling treatments for cancer patients. It presents new possibilities for tailor-made cancer therapy and demands further investigation."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Cite This Page:

University of Edinburgh. "Hormone Therapy Offers New Hope For Ovarian Cancer Patients." ScienceDaily. ScienceDaily, 17 June 2007. <www.sciencedaily.com/releases/2007/06/070615075557.htm>.
University of Edinburgh. (2007, June 17). Hormone Therapy Offers New Hope For Ovarian Cancer Patients. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2007/06/070615075557.htm
University of Edinburgh. "Hormone Therapy Offers New Hope For Ovarian Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2007/06/070615075557.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins