Featured Research

from universities, journals, and other organizations

Sperm Abnormalities Seen In Male Lupus Patients

Date:
June 28, 2007
Source:
John Wiley & Sons, Inc.
Summary:
A new study examined gonad function in male SLE patients and found that they have a high frequency of sperm abnormalities associated with reduced testicular volume.

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years, has improved recently, prompting a shift toward improving quality of life. For men with SLE, concerns have been raised about their future fertility. However, no studies have been conducted to date on testes function and its relevance to sperm abnormalities in male SLE patients. A new study published in the July 2007 issue of Arthritis & Rheumatism examined gonad function in male SLE patients and found that they have a high frequency of sperm abnormalities associated with reduced testicular volume. In addition, the study identified intravenous treatment with the immunosuppressant cyclophosphamide (IV CYC) as the major factor in permanent damage to the testes.

Related Articles


Led by Polyanna Maria F. Soares of the University of Sγo Paulo in Sγo Paulo, Brazil, the study included 35 men with SLE and 35 healthy controls, who underwent an exam of the genitalia, and semen analysis to determine sperm count, morphology and motility. For SLE patients, analysis of antisperm antibodies (which can adversely affect fertilization), testicular ultrasound, and hormone evaluation were also conducted.

The results showed that SLE patients had lower median testicular volumes in both testes, compared with controls, a lower median sperm count, and lower motility. SLE patients also had lower sperm volume and a lower percentage of normally formed sperm. Since all SLE patients had some type of semen abnormality, they were divided into two groups according to the severity: group 1 had abnormal sperm morphology, while group 2 had no sperm or abnormal sperm morphology, coupled with low sperm count and/or low sperm motility. Those in group 2 had a higher frequency of treatment with IV CYC than those in group 1, along with lower testicular volumes and higher levels of follicle-stimulating hormone.

"To our knowledge, this is the first systematic evaluation that has specifically addressed sperm abnormalities in SLE and that clearly demonstrates a high frequency of severe alterations," the researchers state, adding that the study also identifies IV CYC treatment given after puberty as the major factor in permanent sperm damage. IV CYC induces long-lasting damage to developing sperm cells that leads to significant semen alterations. The researchers note that the striking reduction of testicular volumes paralleled the severity of sperm abnormalities, suggesting severe damage to the seminiferous tubules (the tiny tubes in which sperm are produced) in SLE. Follicle-stimulating hormone (FSH) is a major marker of the function of the cells lining the seminiferous tubules and its higher levels in the group 2 SLE patients suggest testicular damage.

The researchers point out that although it is not possible to predict which SLE patients will become infertile, the persistence of abnormal testicular function after approximately five years of IV CYC treatment, combined with elevated FSH and lower testicular volumes, reinforces the need for sperm cryopreservation for male SLE patients undergoing this treatment. Freezing and storing sperm should actually be discussed with all male SLE patients early in the disease course, since for almost a third of patients with semen alterations, the cause has not been recognized. The researchers conclude: "Considering that this disease occurs mainly during reproductive age, a multi-disciplinary approach is essential to identify the potential risk factors for infertility and to offer preventive measures for these patients."

Article: "Gonad Evaluation in Male Systemic Lupus Erythematosus," Pollyana Maria F. Soares, Eduardo Ferreira Borba, Eloisa Bonfa, Jorge Hallak, Andrι Luiz Corrκa, Clovis Artur A. Silva, Arthritis & Rheumatism, July 2007; (DOI: 10.1002/art.22660).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Sperm Abnormalities Seen In Male Lupus Patients." ScienceDaily. ScienceDaily, 28 June 2007. <www.sciencedaily.com/releases/2007/06/070628062209.htm>.
John Wiley & Sons, Inc.. (2007, June 28). Sperm Abnormalities Seen In Male Lupus Patients. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/06/070628062209.htm
John Wiley & Sons, Inc.. "Sperm Abnormalities Seen In Male Lupus Patients." ScienceDaily. www.sciencedaily.com/releases/2007/06/070628062209.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) — Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) — The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins