Featured Research

from universities, journals, and other organizations

Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection

Date:
July 17, 2007
Source:
American Society for Microbiology
Summary:
New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis.

Scanning electron micrograph depicts a grouping of Helicobacter spp. bacteria, magnified 13,951x.
Credit: Janice Carr / Courtesy of CDC: Dr. Patricia Fields, Dr. Collette Fitzgerald

New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis. They report their findings in the July 2007 journal Infection and Immunity.

Helicobacter pylori is a bacterium that colonizes the digestive tract of 50% of the world’s population. Infection commonly occurs in early childhood and can lead to chronic gastritis, peptic ulcer disease and gastric cancer throughout the life of its host. Antibiotics are currently used against H. pylori infection, however increasing resistance as well as high treatment costs and recurrence of infection emphasize the need for an effective, long-lasting vaccine.

In the study mice were immunized in four groups: orally alone, intramuscularly alone, orally followed by intramuscularly, and intramuscularly followed by orally and then challenged orally with H. pylori after three months. Results showed that mice receiving intramuscular immunization alone or a combination of oral and intramuscular vaccinations had significantly reduced bacterial loads and no detectible H. pylori in the intestinal tract. Mice immunized orally alone or intramuscularly followed by orally were not protected and had decreased antibody responses.

“This study demonstrates the ability to induce long-term immunity against H. pylori, provides correlates of protection, and illustrates the crucial role of the immunization route(s),” say the researchers.

Reference: J.M. Taylor, M.E. Ziman, J. Fong, J.V. Solnick, M. Vajdy. 2007. Possible correlates of long-term protection against Helicobacter pylori following systemic or combinations of mucosal and systemic immunizations. Infection and Immunity, 75. 7: 3462-3469


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection." ScienceDaily. ScienceDaily, 17 July 2007. <www.sciencedaily.com/releases/2007/07/070716191705.htm>.
American Society for Microbiology. (2007, July 17). Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/07/070716191705.htm
American Society for Microbiology. "Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection." ScienceDaily. www.sciencedaily.com/releases/2007/07/070716191705.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins