Featured Research

from universities, journals, and other organizations

Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection

Date:
July 17, 2007
Source:
American Society for Microbiology
Summary:
New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis.

Scanning electron micrograph depicts a grouping of Helicobacter spp. bacteria, magnified 13,951x.
Credit: Janice Carr / Courtesy of CDC: Dr. Patricia Fields, Dr. Collette Fitzgerald

New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis. They report their findings in the July 2007 journal Infection and Immunity.

Helicobacter pylori is a bacterium that colonizes the digestive tract of 50% of the world’s population. Infection commonly occurs in early childhood and can lead to chronic gastritis, peptic ulcer disease and gastric cancer throughout the life of its host. Antibiotics are currently used against H. pylori infection, however increasing resistance as well as high treatment costs and recurrence of infection emphasize the need for an effective, long-lasting vaccine.

In the study mice were immunized in four groups: orally alone, intramuscularly alone, orally followed by intramuscularly, and intramuscularly followed by orally and then challenged orally with H. pylori after three months. Results showed that mice receiving intramuscular immunization alone or a combination of oral and intramuscular vaccinations had significantly reduced bacterial loads and no detectible H. pylori in the intestinal tract. Mice immunized orally alone or intramuscularly followed by orally were not protected and had decreased antibody responses.

“This study demonstrates the ability to induce long-term immunity against H. pylori, provides correlates of protection, and illustrates the crucial role of the immunization route(s),” say the researchers.

Reference: J.M. Taylor, M.E. Ziman, J. Fong, J.V. Solnick, M. Vajdy. 2007. Possible correlates of long-term protection against Helicobacter pylori following systemic or combinations of mucosal and systemic immunizations. Infection and Immunity, 75. 7: 3462-3469


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection." ScienceDaily. ScienceDaily, 17 July 2007. <www.sciencedaily.com/releases/2007/07/070716191705.htm>.
American Society for Microbiology. (2007, July 17). Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2007/07/070716191705.htm
American Society for Microbiology. "Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection." ScienceDaily. www.sciencedaily.com/releases/2007/07/070716191705.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins