Featured Research

from universities, journals, and other organizations

Better Sleep May Put Huntington's Disease Sufferers Back On Track

Date:
July 18, 2007
Source:
University of Cambridge
Summary:
Mice carrying the genetic mutation that causes Huntington's disease (HD) showed marked improvements in alertness and their ability to learn after they were given drugs that put them to sleep.

Mice carrying the genetic mutation that causes Huntington's Disease (HD) showed marked improvements in alertness and their ability to learn after they were given drugs that put them to sleep.

Researchers at the University of Cambridge found that daily treatments of Alprazolam or chloral hydrate, two different sedative drugs, enabled them to develop a regular sleep pattern and improved their cognitive function -- their ability to understand and act on information.

According to the Cambridge neuroscientists conducting the research, HD mice have abnormal circadian rhythms; their daily sleeping and waking cycles are disrupted and irregular. Since sleep disruption contributes to problems with perception and learning in healthy people, the team wondered whether the circadian disruption and cognitive disturbances in HD mice were linked.

To test this, drugs were administered to regulate sleep patterns in the mice. The results, published today in the Journal of Neuroscience, show that both drugs caused a noticeable improvement in learning and Alprazolam also improved arousal. The study shows for the first time that treatments aimed at restoring normal sleep-wake activity could slow the cognitive decline that is such a devastating feature of the disease.

Dr. Jenny Morton, lead author of the study, said: "In the future, more attention should be paid to understanding sleep and circadian disturbance in HD. Management of these patterns may not only improve patients ability to think, learn and perform, but would also improve quality of life for both them and their carers."

The results have short-and long-term implications for treatment of HD and for the reversal of the disease's impairments. Recognising that sleep disturbance is a part of the disease means that clinicians should include focussed management of sleep symptoms in their treatment of HD patients.


Story Source:

The above story is based on materials provided by University of Cambridge. Note: Materials may be edited for content and length.


Cite This Page:

University of Cambridge. "Better Sleep May Put Huntington's Disease Sufferers Back On Track." ScienceDaily. ScienceDaily, 18 July 2007. <www.sciencedaily.com/releases/2007/07/070718002121.htm>.
University of Cambridge. (2007, July 18). Better Sleep May Put Huntington's Disease Sufferers Back On Track. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2007/07/070718002121.htm
University of Cambridge. "Better Sleep May Put Huntington's Disease Sufferers Back On Track." ScienceDaily. www.sciencedaily.com/releases/2007/07/070718002121.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins