Featured Research

from universities, journals, and other organizations

Restless Legs Syndrome Affects Nearly Two Percent Of US And UK Children

Date:
August 23, 2007
Source:
University of Illinois at Urbana-Champaign
Summary:
Restless legs syndrome is a common problem in children 8 years of age and older in the United States and the United Kingdom, according to a new report. Nearly 2 percent of children aged 8 to 17 are affected, and a significant proportion of those experience moderate to severe symptoms, including sleep disturbance and negative moods.

Pediatrician Daniel Picchietti led a team that conducted the first population-based prevalence study of restless legs syndrome in children.
Credit: Photo by L. Brian Stauffer

Restless legs syndrome is a common problem in children 8 years of age and older in the United States and the United Kingdom, according to a new report from an international team of researchers.

Nearly 2 percent of children aged 8 to 17 are affected, and a significant proportion of those experience moderate to severe symptoms, including sleep disturbance and negative moods. The report appears in the August issue of the journal Pediatrics.

"This study suggests that restless legs syndrome is common and troublesome in children and adolescents, occurring more frequently than diabetes and epilepsy," said principal investigator Daniel Picchietti, a professor of pediatrics in the University of Illinois College of Medicine and a pediatrician and sleep medicine specialist with the Carle Clinic Association and Carle Foundation Hospital in Urbana, Ill.

Restless legs syndrome (RLS) is a neurological sleep disorder characterized by sensations in the legs that create an urge to move. Symptoms are typically worse at night and during rest. RLS is closely associated with another condition, periodic limb movement disorder, in which a person's legs jerk during sleep. Some people with periodic limb movement disorder also have RLS. Others lack the sensations in the legs that typify RLS.

Most of what is known about restless legs syndrome comes from research on adults. The new analysis is the first population-based prevalence study of RLS in children, and it is the first to use specific pediatric diagnostic criteria. The research team collected detailed data from 10,523 families in the U.S. and U.K.

The new study affirmed that there is a strong genetic component to RLS, Picchietti said. More than 70 percent of the children with RLS had at least one parent with the condition. In 16 percent of the affected children, both parents had RLS symptoms.

Two recent studies -- appearing in July in the New England Journal of Medicine and in Nature Genetics -- found genes associated with RLS.

"Restless legs syndrome runs in families. That is one of the major points of our study, and the discovery of associated genes really supports it," Picchietti said.

Awareness of RLS in adults is increasing (depictions of -- and jokes about -- RLS are appearing more frequently in popular culture). It is less recognized in children, however, and parents and clinicians sometimes dismiss children's complaints about unusual sensations in their legs as nothing more than "growing pains," Picchietti said.

Many adults diagnosed with RLS report that their symptoms began in childhood. In the early 1990s, Picchietti began to notice that some children who came to his office because they had trouble sleeping or paying attention in school had symptoms of RLS. But there was scant research on the prevalence of RLS in children.

The new study included a rigorous analysis of participants' reported symptoms, and excluded those who did not meet all of the National Institutes of Health criteria for diagnosing children with RLS. A child who had periodic limb movements during sleep and no other symptoms of RLS would not be counted, for example. A child who reported leg cramps or growing pains would not be included unless he or she met all of the other diagnostic criteria for RLS.

Some parents are surprised to learn that conditions such as attention deficit hyperactivity disorder and depression appear to be more common in those diagnosed with RLS. Sleep disturbance, by itself, is known to aggravate ADHD and depression, which may explain the association, Picchietti said. But there may also be other reasons for the association.

Picchietti described the new findings as a major step forward in understanding how many children are affected by RLS. "But this is not the final answer," he said. "While some children with RLS had significant sleep disturbance and daytime symptoms, others did not. Which children would benefit from treatment and what those treatments should be are important issues to be addressed. Much more study is needed."

The research team also included clinicians and scientists from Johns Hopkins University; Seton Hall University; New Jersey Neuroscience Institute at JFK Medical Center; Worldwide Epidemiology, GlaxoSmithKline R&D; Premark Services, UK; and the Universitΰ Vita-Salute and IRCCS H San Raffaele, Milan, Italy.


Story Source:

The above story is based on materials provided by University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Urbana-Champaign. "Restless Legs Syndrome Affects Nearly Two Percent Of US And UK Children." ScienceDaily. ScienceDaily, 23 August 2007. <www.sciencedaily.com/releases/2007/08/070822164653.htm>.
University of Illinois at Urbana-Champaign. (2007, August 23). Restless Legs Syndrome Affects Nearly Two Percent Of US And UK Children. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2007/08/070822164653.htm
University of Illinois at Urbana-Champaign. "Restless Legs Syndrome Affects Nearly Two Percent Of US And UK Children." ScienceDaily. www.sciencedaily.com/releases/2007/08/070822164653.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins