Featured Research

from universities, journals, and other organizations

Infection Contributes To The High Rates Of Oropharyngeal Cancers

Date:
August 28, 2007
Source:
John Wiley & Sons, Inc.
Summary:
A review finds an increasing trend in the incidence of oropharyngeal cancers, particularly among men under 45 years old, for which HPV infection is the likely cause. Cancers of the head and neck, which include cancers of the larynx, nasal passages/nose, oral cavity, pharynx, and salivary glands, account for three percent of all newly diagnosed cancers in the U.S. Men are three times more likely to be diagnosed with these cancers than women.

Though the overall incidence of head and neck cancers has fallen in the United States, the rate of oropharyngeal (chiefly, tonsil and base of tongue) cancers is stagnant and appears to be rising is certain populations and these trends are likely due to oncogenic human papillomavirus (HPV) infection.

A review published in the journal Cancer, finds an increasing trend in the incidence of oropharyngeal cancers, particularly among men under 45 years old, for which HPV infection is the likely cause.

Cancers of the head and neck, which include cancers of the larynx, nasal passages/nose, oral cavity, pharynx, and salivary glands, account for three percent of all newly diagnosed cancers in the U.S. Men are three times more likely to be diagnosed with these cancers than women.

Of the estimated 45,000 new cases of head and neck cancers expected this year, approximately 10,000 are cancers of the pharynx (chiefly the oropharynx). Though the prognosis for these cancers is excellent when caught early, more than half of them are identified in advanced stages, when the prognosis is far worse, making prevention critical to saving lives.

In their review, Erich M. Sturgis, M.D., M.P.H. and Paul Cinciripini, Ph.D. of The University of Texas M. D. Anderson Cancer Center in Houston, conclude that the stagnate incidence rates of oropharyngeal cancers, particularly cancers of the tonsil and base of tongue, in the face of declines in tobacco use, the principal cause of head and neck cancers, are likely explained by rising prevalence of oropharyngeal exposure to an oncogenic virus.

They say the literature points to exposure to HPV -- especially strain 16 -- as having the strongest association to oropharyngeal cancers. However, the authors suggest that a recently approved HPV vaccine may ultimately have a significant impact on the incidence of oropharyngeal tumors.

"While the cervical cancer and dysplasia prevention policy of HPV16/18 vaccination of young women and adolescent females are commended, we fear that vaccination programs limited to females will only delay the potential benefit in prevention of HPV16/18 associated oropharyngeal cancers, which typically occur in men," conclude the authors.

The authors "encourage the rapid study of the efficacy and safety of these vaccines in males and, if successful, the recommendation of vaccination of young adult and adolescent males."

Article: "Trends in Head and Neck Cancer Incidence in Relation to Smoking Prevalence: An Emerging Epidemic of Human Papillomavirus-Associated Cancers"," Erich M. Sturgis, M.D., M.P.H., and Paul M. Cinciripini, Cancer; Published Online: August 27, 2007 (DOI: 10.1002/cncr. 22963); Print Issue Date: October 1, 2007.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Infection Contributes To The High Rates Of Oropharyngeal Cancers." ScienceDaily. ScienceDaily, 28 August 2007. <www.sciencedaily.com/releases/2007/08/070827095218.htm>.
John Wiley & Sons, Inc.. (2007, August 28). Infection Contributes To The High Rates Of Oropharyngeal Cancers. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2007/08/070827095218.htm
John Wiley & Sons, Inc.. "Infection Contributes To The High Rates Of Oropharyngeal Cancers." ScienceDaily. www.sciencedaily.com/releases/2007/08/070827095218.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins