Featured Research

from universities, journals, and other organizations

More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer

Date:
August 29, 2007
Source:
Journal of the National Cancer Institute
Summary:
More prostate cancers were detected among men who were screened every two years than men screened every four years, according to a new study. But the shorter time between screenings did not reduce the number of aggressive cancers found between the scheduled screening tests.

More prostate cancers were detected among men who were screened every two years than men screened every four years, according to a study published online August 28 in the Journal of the National Cancer Institute. But the shorter time between screenings did not reduce the number of aggressive cancers found between the scheduled screening tests.

Since the introduction of PSA (prostate specific antigen) testing in the late 1980s, the incidence of prostate cancer has risen dramatically. The rise is mainly due to widespread screening of asymptomatic men. Screening for prostate cancer is a controversial issue because evidence is lacking that PSA screening prevents prostate cancer deaths. Looking at the rate of interval cancers--cancers diagnosed based on symptoms during the years between screening tests--may give an indication of how well a screening program is working.

Monique Roobol, Ph.D., of Erasmus Medical Centre in Rotterdam, The Netherlands, and colleagues conducted a study to determine whether the time between PSA screenings influenced the incidence of prostate cancer. They analyzed data collected at two European medical centers that participated in the European Randomized Study of Screening for Prostate Cancer.

At a center in Gothenburg, Sweden, 4,202 men were screened every two years, and in Rotterdam, The Netherlands, 13,301 men were screened every four years. The researchers compared both the number and characteristics of the interval prostate cancers diagnosed in these men. Serious, potentially life threatening interval cancers were analyzed separately.

Over a period of ten years, the overall incidence of prostate cancer was higher among men screened every two years than among those screened every four years (13.14 percent vs. 8.41 percent). But the total number of interval cancers that were diagnosed between screening tests was 31 (0.74 percent) in Gothenburg and 57 (0.43 percent) in Rotterdam. This difference in the number of interval cancers and the number of aggressive interval cancers at the two centers was not statistically significant, indicating that the two-year screening program did not reduce the number of interval cancers as would be expected.

"It is therefore more realistic to believe that each screening will again lead to prostate cancer diagnoses among some men from a large pool harboring small and often clinically insignificant disease and thus that more cancers were detected in Sweden because screening was more frequent," the authors write. Additionally, larger cancers seem to be identified with equal effectiveness if screening takes place every 2 or 4 years.

In an accompanying editorial, E. David Crawford, M.D., of the University of Colorado Health Sciences Center in Aurora discusses the controversy surrounding prostate cancer screening and the challenge in determining how often to screen.

"Although many of us believe that early detection is saving lives, definitive evidence is lacking," Crawford writes.

Citations:

Article: Roobol MJ, Grenabo A, Schrφder FH, Hugosson J. Interval Cancers in Prostate Cancer Screening: Comparing 2- and 4-Year Screening Intervals in the European Randomized Study of Screening for Prostate Cancer, Gothenburg and Rotterdam. J Natl Cancer Inst 2007; 99:1296-1303

Editorial: Crawford ED. Is a Screening Interval of Every 4 Years for Prostate Cancer Acceptable" J Natl Cancer Inst 2007; 99: 1279-1280

 


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer." ScienceDaily. ScienceDaily, 29 August 2007. <www.sciencedaily.com/releases/2007/08/070828175444.htm>.
Journal of the National Cancer Institute. (2007, August 29). More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2007/08/070828175444.htm
Journal of the National Cancer Institute. "More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/08/070828175444.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins