Featured Research

from universities, journals, and other organizations

More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer

Date:
August 29, 2007
Source:
Journal of the National Cancer Institute
Summary:
More prostate cancers were detected among men who were screened every two years than men screened every four years, according to a new study. But the shorter time between screenings did not reduce the number of aggressive cancers found between the scheduled screening tests.

More prostate cancers were detected among men who were screened every two years than men screened every four years, according to a study published online August 28 in the Journal of the National Cancer Institute. But the shorter time between screenings did not reduce the number of aggressive cancers found between the scheduled screening tests.

Related Articles


Since the introduction of PSA (prostate specific antigen) testing in the late 1980s, the incidence of prostate cancer has risen dramatically. The rise is mainly due to widespread screening of asymptomatic men. Screening for prostate cancer is a controversial issue because evidence is lacking that PSA screening prevents prostate cancer deaths. Looking at the rate of interval cancers--cancers diagnosed based on symptoms during the years between screening tests--may give an indication of how well a screening program is working.

Monique Roobol, Ph.D., of Erasmus Medical Centre in Rotterdam, The Netherlands, and colleagues conducted a study to determine whether the time between PSA screenings influenced the incidence of prostate cancer. They analyzed data collected at two European medical centers that participated in the European Randomized Study of Screening for Prostate Cancer.

At a center in Gothenburg, Sweden, 4,202 men were screened every two years, and in Rotterdam, The Netherlands, 13,301 men were screened every four years. The researchers compared both the number and characteristics of the interval prostate cancers diagnosed in these men. Serious, potentially life threatening interval cancers were analyzed separately.

Over a period of ten years, the overall incidence of prostate cancer was higher among men screened every two years than among those screened every four years (13.14 percent vs. 8.41 percent). But the total number of interval cancers that were diagnosed between screening tests was 31 (0.74 percent) in Gothenburg and 57 (0.43 percent) in Rotterdam. This difference in the number of interval cancers and the number of aggressive interval cancers at the two centers was not statistically significant, indicating that the two-year screening program did not reduce the number of interval cancers as would be expected.

"It is therefore more realistic to believe that each screening will again lead to prostate cancer diagnoses among some men from a large pool harboring small and often clinically insignificant disease and thus that more cancers were detected in Sweden because screening was more frequent," the authors write. Additionally, larger cancers seem to be identified with equal effectiveness if screening takes place every 2 or 4 years.

In an accompanying editorial, E. David Crawford, M.D., of the University of Colorado Health Sciences Center in Aurora discusses the controversy surrounding prostate cancer screening and the challenge in determining how often to screen.

"Although many of us believe that early detection is saving lives, definitive evidence is lacking," Crawford writes.

Citations:

Article: Roobol MJ, Grenabo A, Schröder FH, Hugosson J. Interval Cancers in Prostate Cancer Screening: Comparing 2- and 4-Year Screening Intervals in the European Randomized Study of Screening for Prostate Cancer, Gothenburg and Rotterdam. J Natl Cancer Inst 2007; 99:1296-1303

Editorial: Crawford ED. Is a Screening Interval of Every 4 Years for Prostate Cancer Acceptable" J Natl Cancer Inst 2007; 99: 1279-1280


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer." ScienceDaily. ScienceDaily, 29 August 2007. <www.sciencedaily.com/releases/2007/08/070828175444.htm>.
Journal of the National Cancer Institute. (2007, August 29). More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2007/08/070828175444.htm
Journal of the National Cancer Institute. "More Prostate Cancer Screening Has Little Effect On Detection Of Aggressive Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/08/070828175444.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins