Featured Research

from universities, journals, and other organizations

Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics

Date:
September 7, 2007
Source:
Journal of Clinical Investigation
Summary:
Type 1 diabetes occurs when immune cells destroy pancreatic insulin producing beta-cells. It was hoped that islet transplantation would provide a cure for the disease, however, transplant success is short-lived and accompanied by significant side effects. New data indicate that the immunosuppressive drugs used to prevent islet transplant rejection suppress beta-cell regeneration in diabetic mice, raising the possibility that identifying immunosuppressive drugs that do not inhibit beta-cell regeneration might lead to successful regenerative islet transplantation.

Type 1 diabetes is caused when immune cells attack and destroy the insulin producing beta-cells of the pancreas.

Related Articles


Although insulin injections have changed the life of type I diabetics, they neither cure the disease nor prevent its severe complications. It was hoped that islet transplantation would provide a cure, however, transplant success is short-lived and accompanied by significant side effects.

New data from Yuval Dor and colleagues at the Hebrew University-Hadassah Medical School, Jerusalem, have indicated that the immunosuppressive drugs used to prevent rejection of islet transplants suppress beta-cell regeneration in diabetic mice.

As mentioned by the authors and discussed in the accompanying commentary by Klaus Kaestner from the University of Pennsylvania, Philadelphia, this raises the possibility that if immunosuppressive drugs that do not inhibit beta-cell regeneration can be identified successful regenerative islet transplantation might become a reality.

Article: Recovery from diabetes in mice by beta-cell regeneration


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics." ScienceDaily. ScienceDaily, 7 September 2007. <www.sciencedaily.com/releases/2007/09/070904175432.htm>.
Journal of Clinical Investigation. (2007, September 7). Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2007/09/070904175432.htm
Journal of Clinical Investigation. "Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904175432.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins