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Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics

Date:
September 7, 2007
Source:
Journal of Clinical Investigation
Summary:
Type 1 diabetes occurs when immune cells destroy pancreatic insulin producing beta-cells. It was hoped that islet transplantation would provide a cure for the disease, however, transplant success is short-lived and accompanied by significant side effects. New data indicate that the immunosuppressive drugs used to prevent islet transplant rejection suppress beta-cell regeneration in diabetic mice, raising the possibility that identifying immunosuppressive drugs that do not inhibit beta-cell regeneration might lead to successful regenerative islet transplantation.

Type 1 diabetes is caused when immune cells attack and destroy the insulin producing beta-cells of the pancreas.

Although insulin injections have changed the life of type I diabetics, they neither cure the disease nor prevent its severe complications. It was hoped that islet transplantation would provide a cure, however, transplant success is short-lived and accompanied by significant side effects.

New data from Yuval Dor and colleagues at the Hebrew University-Hadassah Medical School, Jerusalem, have indicated that the immunosuppressive drugs used to prevent rejection of islet transplants suppress beta-cell regeneration in diabetic mice.

As mentioned by the authors and discussed in the accompanying commentary by Klaus Kaestner from the University of Pennsylvania, Philadelphia, this raises the possibility that if immunosuppressive drugs that do not inhibit beta-cell regeneration can be identified successful regenerative islet transplantation might become a reality.

Article: Recovery from diabetes in mice by beta-cell regeneration


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics." ScienceDaily. ScienceDaily, 7 September 2007. <www.sciencedaily.com/releases/2007/09/070904175432.htm>.
Journal of Clinical Investigation. (2007, September 7). Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/09/070904175432.htm
Journal of Clinical Investigation. "Immunosuppressive Drugs Are A Double-edged Sword To Type 1 Diabetics." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904175432.htm (accessed July 31, 2014).

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