Featured Research

from universities, journals, and other organizations

Cancer Stem Cell Subpopulation Drives Metastasis Of Human Pancreatic Cancer

Date:
September 13, 2007
Source:
Cell Press
Summary:
Scientists have identified a distinct subpopulation of cancer stem cells (CSC) that is responsible for metastasis of a deadly human pancreatic cancer. The research provides insight into the role of CSCs in cancer initiation, progression and metastasis, and suggests new directions for development of more effective therapeutics.

Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. The research provides insight into the role of CSCs in cancer initiation, progression, and metastasis and suggests new directions for development of more effective therapeutics.

Pancreatic adenocarcinoma ranks as the fourth leading cause of cancer death and is relatively incurable due to early metastatic spread and high resistance to radiation and chemotherapy. In order to better understand the pathology of this deadly cancer, scientists have recently begun to explore the role of CSCs in pancreatic tumors. CSCs are thought to be a small population of tumor cells that have similar properties to normal stem cells in that they are self-replicating and capable of giving rise to populations of differentiated cells.

Dr. Christopher Heeschen from the Department of Surgery at Ludwig-Maximilians-University in Munich, Germany led a study to examine the role of CSCs in pancreatic cancer.

The researchers discovered that human pancreatic cancer tissue contains tumorigenic and chemotherapy resistant stem cells defined by expression of CD133, a surface marker expressed by a variety of normal and malignant stem cells. They identified a distinct subset of cells expressing both CD133 and the chemokine receptor CXCR4, which plays a key role in blood cell migration, in the invasive front of the tumor. Implantation of isolated CD133+/CXCR4+ cells into mice resulted in metastatic tumor development, identifying them as CSCs.

Cancer metastasis was abolished by inhibiting CXCR4 or by transplanting CD133+/CXCR4- cells instead, underlining the importance of CXCR4 for the invasive cell behavior. Clinical studies revealed that tumor samples with a high number of CXCR4+ cells were more migratory and came from patients that suffered from more advanced metastatic disease. This important correlation may provide more accurate individual prognoses, allowing for improved selection of therapeutic agents.

These findings demonstrate for the first time that a specific CD133+/CXCR4+ cancer stem cell population present at the tumor-host interface is critically involved in pancreatic tumor metastasis. "The further molecular characterization of the pancreatic CSCs identified in the present study will be crucial for the development of new therapeutic strategies to eliminate these tumorigenic and metastatic cells. This may eventually provide a more effective treatment for our patients suffering from this deadly disease. In this respect, the demonstrated possibility of expanding pancreatic CSCs in vitro will dramatically help us in the evaluation of drug efficacy," offers Dr. Heeschen.

The researchers include Patrick C. Hermann, Stephan L. Huber, Tanja Herrler of Ludwig-Maximilians-University in Munich; Alexandra Aicher of J.W. Goethe University in Frankfurt; Joachim W. Ellwart of Helmholtz Center for Environment and Health in Munich; and Markus Guba, Christiane J. Bruns, and Christopher Heeschen of Ludwig-Maximilians-University in Munich.

This work was supported by the Deutsche Forschungsgemeinschaft.

Reference: Hermann et al.: "Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer." Publishing in Cell Stem Cell 1, 313--323, September 2007. DOI 10.1016/j.stem.2007.06.002


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Cancer Stem Cell Subpopulation Drives Metastasis Of Human Pancreatic Cancer." ScienceDaily. ScienceDaily, 13 September 2007. <www.sciencedaily.com/releases/2007/09/070912121905.htm>.
Cell Press. (2007, September 13). Cancer Stem Cell Subpopulation Drives Metastasis Of Human Pancreatic Cancer. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/09/070912121905.htm
Cell Press. "Cancer Stem Cell Subpopulation Drives Metastasis Of Human Pancreatic Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/09/070912121905.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins