Featured Research

from universities, journals, and other organizations

Frequent Hemodialysis At Night May Improve Some Outcomes For Patients With End-stage Kidney Disease

Date:
September 21, 2007
Source:
JAMA and Archives Journals
Summary:
Patients who received hemodialysis at night six times a week for treatment of end-stage kidney disease had improvements on certain outcomes, including reduced need for blood pressure medications and improvement in selected quality of life measures, compared to patients who received conventional hemodialysis three times weekly, according to a new article.

Patients who received hemodialysis at night six times a week for treatment of end-stage kidney disease had improvements on certain outcomes, including reduced need for blood pressure medications and improvement in selected quality of life measures, compared to patients who received conventional hemodialysis three times weekly, according to an article in the September 19 issue of JAMA.

Related Articles


Despite advances in dialysis and medical therapies, patients with end-stage renal (kidney) disease (ESRD) have annual rates of death that exceed 15 percent. Cardiovascular disease, specifically heart failure or sudden death, is responsible for the majority of deaths, according to background information in the article. Some recent studies have suggested that nocturnal hemodialysis might improve clinical outcomes in ESRD patients.

Bruce F. Culleton, M.D., M.Sc., formerly of the University of Calgary, Alberta, Canada, and colleagues conducted a study to determine the effects of frequent nocturnal hemodialysis compared with conventional hemodialysis on certain outcomes, including left ventricular (LV) mass, health-related quality of life (HRQOL), blood pressure and mineral metabolism.

The randomized controlled trial was conducted at two Canadian university centers between August 2004 and December 2006. A total of 52 patients undergoing hemodialysis were recruited. Participants were randomly assigned to receive nocturnal hemodialysis six times weekly or conventional hemodialysis three times weekly.

"Our findings indicate that frequent nocturnal hemodialysis improves LV mass, systemic blood pressure, abnormalities of mineral metabolism, and possibly HRQOL compared with conventional thrice-weekly hemodialysis," the authors write.

LV mass decreased by an average of 13.8 grams in the nocturnal hemodialysis group and increased by 1.5 grams in the conventional hemodialysis group, for a difference of 15.3 grams. Frequent nocturnal hemodialysis was associated with a reduction in or discontinuation of antihypertensive medications (16/26 patients in the nocturnal hemodialysis group vs. 3/25 patients in the conventional hemodialysis group). No benefit in anemia management was seen with nocturnal hemodialysis.

"If it is found that nocturnal hemodialysis has a favorable cost-benefit profile compared with other dialysis therapies, then consideration should be given to expansion of nocturnal hemodialysis centers, specifically for patients who wish to trade a more demanding therapy for less cardiovascular risk and a potential of improved quality of life," the researchers conclude.

Referenc: JAMA. 2007;298(11):1291-1299.

Editorial: Frequent Nocturnal Hemodialysis--A Step Forward?

In an accompanying editorial, Alan S. Kliger, M.D., of the Hospital of St. Raphael and Yale University, New Haven, Conn., comments on the study examining nocturnal hemodialysis.

"The randomized controlled trial (RCT) by Culleton et al is important for nephrology, clearly demonstrating reduced left ventricular hypertrophy with nocturnal hemodialysis. It would be interesting to see the effect of nocturnal hemodialysis on cardiac structure and function beyond the 6-month study period examined. While future studies may provide additional information, the RCT by Culleton et al suggests that nocturnal hemodialysis may help improve the high morbidity and mortality of North American dialysis patients."

Reference for editorial: JAMA. 2007;298(11):1331-1333.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Frequent Hemodialysis At Night May Improve Some Outcomes For Patients With End-stage Kidney Disease." ScienceDaily. ScienceDaily, 21 September 2007. <www.sciencedaily.com/releases/2007/09/070918161613.htm>.
JAMA and Archives Journals. (2007, September 21). Frequent Hemodialysis At Night May Improve Some Outcomes For Patients With End-stage Kidney Disease. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2007/09/070918161613.htm
JAMA and Archives Journals. "Frequent Hemodialysis At Night May Improve Some Outcomes For Patients With End-stage Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2007/09/070918161613.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins