Featured Research

from universities, journals, and other organizations

Preventing Neurodegenerative Diseases By Studying Proteins In The Brain

Date:
October 10, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have made the most complete list so far of the proteins present in the cerebral cortex -- the outermost layer of the brain that plays a central role in memory, language, cognition, and consciousness. The cerebral cortex is also the part of the brain that contains the hallmarks of many neurodegenerative diseases, so these results could help understand how such diseases develop and maybe find ways to slow it down. Most neurodegenerative diseases develop in specific regions of the brain. For instance, loss of neurons due to Alzheimer's disease occur mostly in the cerebral cortex and hippocampus, and degeneration of neurons in Parkinson's disease largely centers on an area in the back of the brain called the brainstem -- at least in the early stage of the disease.

Researchers report in Molecular & Cellular Proteomics the most complete list so far of the proteins present in the cerebral cortex – the outermost layer of the brain that plays a central role in memory, language, cognition, and consciousness. The cerebral cortex is also the part of the brain that contains the hallmarks of many neurodegenerative diseases, so these results could help understand how such diseases develop and maybe find ways to slow it down.

Most neurodegenerative diseases develop in specific regions of the brain. For instance, loss of neurons due to Alzheimer’s disease (AD) occur mostly in the cerebral cortex and hippocampus, and degeneration of neurons in Parkinson’s disease largely centers on an area in the back of the brain called the brainstem – at least in the early stage of the disease.

Jing Zhang and colleagues identified over 800 different proteins in a part of the cortex near the forehead called the frontal cortex. This region of the brain is involved in many neurodegenerative diseases in which intellectual function deteriorates over time, including AD, Parkinson’s disease with dementia (PDD), and dementia with Lewy body (DLB) disease, and frontotemporal lobar degeneration (FTLD).

The proteins identified in this study perform various functions inside the cell, such as the transport of other proteins, the activation of neighboring proteins, and the catalysis of biochemical reactions. Among these proteins, the scientists found that at least half a dozen are known to be associated with neurodegenerative diseases, but examining the role of the other proteins may show that some of them also are involved in these diseases.

The scientists also found that 17 percent of the identified proteins are also present in the cerebrospinal fluid (CSF) – a watery fluid that surrounds and protects the brain and spinal cord. Since proteins in the CSF are more accessible clinically than those in the cortex, understanding how proteins present in both the frontal cortex and CSF are involved in neurodegenerative diseases could help improve their diagnosis and assess disease progression.

Taken together, the proteins identified in this study provide important information to ultimately understand how the frontal cortex works and what goes wrong in many neurodegenerative diseases, the researchers conclude. Zhang and his team are now trying to determine the most comprehensive list of all the proteins that are working in other brain regions, such as the middle brain, which is heavily involved in movement disorders such as Parkinson’s disease.

Article: “Proteomics Identification of Proteins in Human Cortex Using Multidimensional Separations and MALDI Tandem Mass Spectrometer,” by Sheng Pan, Min Shi, Jinghua Jin, Roger L. Albin, Andy Lieberman, Marla Gearing, Biaoyang Lin, Catherine Pan, Xiaowei Yan, Daniel T. Kashima, and Jing Zhang, October 2007


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Preventing Neurodegenerative Diseases By Studying Proteins In The Brain." ScienceDaily. ScienceDaily, 10 October 2007. <www.sciencedaily.com/releases/2007/10/071005150411.htm>.
American Society for Biochemistry and Molecular Biology. (2007, October 10). Preventing Neurodegenerative Diseases By Studying Proteins In The Brain. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2007/10/071005150411.htm
American Society for Biochemistry and Molecular Biology. "Preventing Neurodegenerative Diseases By Studying Proteins In The Brain." ScienceDaily. www.sciencedaily.com/releases/2007/10/071005150411.htm (accessed July 30, 2014).

Share This




More Mind & Brain News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins