Featured Research

from universities, journals, and other organizations

Cigarette Smoking May Accelerate Disability In Those With MS

Date:
October 14, 2007
Source:
University at Buffalo
Summary:
Persons with multiple sclerosis who smoke risk increasing the amount of brain tissue shrinkage, a consequence of MS, and the subsequent severity of their disease, new research has shown.

Persons with multiple sclerosis who smoke risk increasing the amount of brain tissue shrinkage, a consequence of MS, and the subsequent severity of their disease, new research conducted at the Buffalo Neuroimaging Analysis Center (BNAC) at the University at Buffalo has shown.

The results are based on magnetic resonance images (MRIs) of smokers and nonsmokers in 368 MS patients treated in UB's Jacobs Neurological Institute, the university's Department of Neurology in its School of Medicine and Biomedical Sciences.

"Cigarette smoke has many properties that are toxic to the central nervous system, and cigarette smoking has been linked to higher susceptibility and risk of progressive multiple sclerosis," said Robert Zivadinov, M.D., Ph.D., UB professor of neurology, director of the BNAC and first author on the study.

"Interactions between cigarette smoking and genetic and immunologic factors may point to mechanisms in disease pathogenesis. No previous studies have investigated differences in MRI characteristics between MS cigarette smokers and MS nonsmokers," he said.

The study included patients from the three most common forms of MS: 253 had relapsing-remitting MS -- acute attacks with full or partial recovery; nine had primary-progressive MS -- steady worsening from onset; and 90 had secondary-progressive MS, characterized by occasional attacks and sustained progression. Another 16 participants had experienced their first MS onset.

Patients ranged in age from 35-55 years, and had been living with MS for an average of 13 years. The Expanded Disability Status Scale (EDSS), an average number derived from measures of various functions of the central nervous system based on scales ranging from 0 to 10, was 3.1. The higher the number, the greater the disability.

Within the study cohort, 128 had a history of smoking: 96 were active smokers who had smoked more than 10 cigarettes-per-day in the three months prior to the study start, and 32 were former smokers who had smoked cumulatively for at least 6 months sometime in the past. The remaining 240 participants had no active smoking exposure.

The average smoking duration was 17.6 years and the average number of cigarettes smoked per day was 17. There were no significant differences between smokers and nonsmokers based on age, disease duration, disease course and total lifetime use of disease-modifying drugs.

Analysis and comparison of the MRIs from smokers and nonsmokers showed that the smokers had significantly higher disability scores and lower brain volume than the nonsmokers. There also was a significant relationship between a higher number of packs-per-day smoked and lower volume of the neocortex, the portion of the cerebral cortex that serves as the center of higher mental functions for humans.

There were no significant differences in any of the clinical findings between active and former smokers.

"Smoking appears to influence the severity of MS and to accelerate brain atrophy and the disruption of the blood-brain barrier in MS patients," said Zivadinov. "MS patients should be counseled to stop smoking, or at least to cut down so they can preserve as much brain function as possible."

Results of the research were presented Oct. 13, 2007 at the 23rd Congress of the European Committee for the Treatment and Research in Multiple Sclerosis in Prague, Czech Republic.

Additional researchers on the study, all from the BNAC or the JNI, were Milena Stosic, M.D., Nadir Abdelrahman, M.D., Barbara E. Teter, Ph.D., Frederick E. Munschauer, M.D., Sara Hussein, Jackie Durfee, Michael G. Dwyer, Jennifer L. Cox, Ph.D., Nima Hani, Fernando Nussenbaum and Bianca Weinstock-Guttman, M.D.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Cigarette Smoking May Accelerate Disability In Those With MS." ScienceDaily. ScienceDaily, 14 October 2007. <www.sciencedaily.com/releases/2007/10/071013083426.htm>.
University at Buffalo. (2007, October 14). Cigarette Smoking May Accelerate Disability In Those With MS. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2007/10/071013083426.htm
University at Buffalo. "Cigarette Smoking May Accelerate Disability In Those With MS." ScienceDaily. www.sciencedaily.com/releases/2007/10/071013083426.htm (accessed August 30, 2014).

Share This




More Mind & Brain News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins