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Toward A Better Drug For Treating Muscle, Bone Loss In Elderly Men

Date:
October 19, 2007
Source:
American Chemical Society
Summary:
The search for alternatives to steroid medications for treating millions of Baby Boomer males with age-related declines in the sex hormone testosterone has led researchers to report development of a nonsteroidal compound that shows promise as a new treatment for loss of muscle mass, bone tissue, and other problems linked to low testosterone.

Multiple fluorescent dyes reveal sites of new bone formation caused by a promising nonsteroidal compound that stimulates bone formation and increases bone density and strength.
Credit: Courtesy of Arjan van Oeveren, Ligand Pharmaceuticals, Inc.

The search for alternatives to steroid medications for treating millions of Baby Boomer males with age-related declines in the sex hormone testosterone has led researchers in California to report development of a nonsteroidal compound that shows promise as a new treatment for loss of muscle mass, bone tissue, and other problems linked to low testosterone. .

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In the report, Arjan van Oeveren and colleagues point out that the potential side effects of testosterone, a steroid medication, limit its use to older men with low testosterone levels. Testosterone replacement therapy may increase the risk of prostate cancer and stroke, for instance, and cannot be given orally. People take it via skin patches or rub-on gels.

The new study describes a nonsteroidal compound that in lab rats attaches to testosterone receptors in cells and triggers the same desired effects as actual testosterone in tests in laboratory animals. In comparison to other testosterone replacement treatments, the compound showed similar improvement in muscle mass and strength while having little effect on the prostate, the researchers say. It also significantly improved bone density and strength in the lab rats.

This study, "Substituted 6-(1-Pyrrolidine) quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators," will appear in the Oct. 18 issue of the ACS' Journal of Medicinal Chemistry.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Toward A Better Drug For Treating Muscle, Bone Loss In Elderly Men." ScienceDaily. ScienceDaily, 19 October 2007. <www.sciencedaily.com/releases/2007/10/071015093525.htm>.
American Chemical Society. (2007, October 19). Toward A Better Drug For Treating Muscle, Bone Loss In Elderly Men. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/10/071015093525.htm
American Chemical Society. "Toward A Better Drug For Treating Muscle, Bone Loss In Elderly Men." ScienceDaily. www.sciencedaily.com/releases/2007/10/071015093525.htm (accessed October 25, 2014).

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