Featured Research

from universities, journals, and other organizations

Enzyme's Cancer-promoting Activities Linked To Inactivation Of 'Genome Guardian'

Date:
October 16, 2007
Source:
Baylor College Of Medicine
Summary:
The enzyme WIP1 becomes cancer-causing when there is too much of it, preventing the p53 gene from protecting the genome against dangerous DNA mutations, according to new research. The gene p53 prevents a damaged or stressed cell from dividing. When these damaged cells cannot reproduce, they cannot repeat the genetic changes that have led to their damage.

The enzyme WIP1 (wild-type p53-induced phosphatase one) becomes cancer-causing when there is too much of it, preventing the p53 gene from protecting the genome against dangerous DNA mutations, said Baylor College of Medicine researchers in a report that appears in the journal Cancer Cell.

Related Articles


The gene p53 prevents a damaged or stressed cell from dividing, said Dr. Lawrence A. Donehower, professor of molecular virology and microbiology and molecular and cellular biology at BCM. When these damaged cells cannot reproduce, they cannot repeat the genetic changes that have led to their damage. In the research described in this report, he and his colleagues describe how WIP1 interacts with both p53 and its off-switch, a protein called Mdm2.

"In the cell, p53 helps to repair cell damage by eliminating those cells with damaged or mutated DNA," said Donehower. "Once that task is accomplished, Mdm2 builds up and turns off p53, bringing the situation back to normal."

"After p53 has finished its activity, WIP1 removes a phosphate molecule, which allows Mdm2 to degrade the p53," said Donehower. However, when WIP1 is overexpressed, meaning there is extra enzyme in the cell, it stabilizes Mdm2, increasing the rate of p53 degradation.

The fact that WIP1 is increased in some breast, ovarian and brain tumors buttresses its role in causing cells to become cancerous, said Donehower.

"In some tumor types, if you have WIP1 overexpression, the prognosis is poorer than if you don't," he said. In fact, tumors with high levels of WIP1 rarely have mutations in p53, he said.

"If you have a lot of this protein in the cell, it's continually knocking down p53. The tumor doesn't need to mutate the p53 gene," he said.

Others who took part in this research include Xiongbin Lu, Ou Ma and Thuy-Ai Nguyen, all of BCM, Stephen N. Jones of the University of Massachusetts Medical School in Worcester, and Moshe Oren of the Weizmann Institute in Rehovot, Israel.

Funding for this research came from the National Institutes of Health, the A-T Children's Project and the U.S. Department of Defense Breast Cancer Research Program.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Enzyme's Cancer-promoting Activities Linked To Inactivation Of 'Genome Guardian'." ScienceDaily. ScienceDaily, 16 October 2007. <www.sciencedaily.com/releases/2007/10/071015215101.htm>.
Baylor College Of Medicine. (2007, October 16). Enzyme's Cancer-promoting Activities Linked To Inactivation Of 'Genome Guardian'. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/10/071015215101.htm
Baylor College Of Medicine. "Enzyme's Cancer-promoting Activities Linked To Inactivation Of 'Genome Guardian'." ScienceDaily. www.sciencedaily.com/releases/2007/10/071015215101.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins