Featured Research

from universities, journals, and other organizations

Parkinson's Disease: Nicotine Reduces Levodopa-induced Dyskinesias

Date:
October 24, 2007
Source:
The Parkinson's Institute
Summary:
Research shows that intermittent nicotine treatment reduces medication-induced dyskinesias by as much as 50 percent. Dyskinesias is uncontrolled movements of the head and limbs.

The Parkinson's Institute and Clinical Center has announced research showing that intermittent nicotine treatment reduces medication-induced dyskinesias by as much as 50 percent in models of Parkinson's disease. Levodopa, the most common drug used to treat Parkinson's disease, is initially very effective.

Related Articles


However, long-term treatment often lessens efficacy and causes multiple complications, including abnormal involuntary movements, called dyskinesias. These uncontrolled movements of the head and limbs tend to worsen over time and can become as debilitating as Parkinson's disease itself.

Currently, there are only limited therapeutic options for dyskinesias, including reduction in levodopa dose, amantadine administration, and deep brain stimulation for a limited number of patients.

Most of the research on tobacco has focused on its detrimental health effects. Studies conducted over the last 40 years show that the incidence of Parkinson's disease is about 50 percent less in smokers than in the general population. Recent studies in experimental models suggest that the nicotine in smoke may be responsible for this neuroprotective effect.

In addition, this is the first research to show that nicotine may also reduce levodopa-induced dyskinesias. With an estimated 1.5 million Parkinson's disease patients in the United States, and levodopa being the top prescribed medication for Parkinson's disease, this study has far-reaching implications for the treatment of Parkinson's disease.

"Our hope is that this research represents a useful treatment strategy to reduce the dyskinesias that so many Parkinson's disease patients suffer, "said Dr. Maryka Quik of the Parkinson's Institute and Clinical Center in Sunnyvale. "Reducing the side effects of levodopa makes it a much more effective and long-term treatment."

Lead by senior research scientist, Maryka Quik, Ph.D., the research will be published in an upcoming issue of the Annals of Neurology.


Story Source:

The above story is based on materials provided by The Parkinson's Institute. Note: Materials may be edited for content and length.


Cite This Page:

The Parkinson's Institute. "Parkinson's Disease: Nicotine Reduces Levodopa-induced Dyskinesias." ScienceDaily. ScienceDaily, 24 October 2007. <www.sciencedaily.com/releases/2007/10/071024093555.htm>.
The Parkinson's Institute. (2007, October 24). Parkinson's Disease: Nicotine Reduces Levodopa-induced Dyskinesias. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2007/10/071024093555.htm
The Parkinson's Institute. "Parkinson's Disease: Nicotine Reduces Levodopa-induced Dyskinesias." ScienceDaily. www.sciencedaily.com/releases/2007/10/071024093555.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins