Featured Research

from universities, journals, and other organizations

New Source Of Islet Cells For Islet Transplantion For Type 1 Diabetes

Date:
October 25, 2007
Source:
World Journal of Gastroenterology
Summary:
Islets transplantation is one promising approach to type 1 diabetes treatment, but it is limited by the shortage of islet cells. To address this issue, scientists have successfully shortened the process of differentiation and enhanced the output of insulin-producing cells.

The shortage of islet cells limits the development of islet transplantation. One new approach has been suggested to improve the output of islet cells. This article* is expected to bring benefit to diabetic patients.

The article describes the differentiation of rat pancreatic ductal epithelial cells into insulin-producing cells by the transfection of PDX-1. In recent years, though great efforts have been made to differentiate embryonic stem cells, pancreatic ductal epithelial multipotent progenitor cells and bone marrow stem cells into islet cells, the process of cell differentiation and growth is long. Moreover, the amount of islet cells of differentiation, and the insulin released by islets, is not enough to meet the clinical needs.

To shorten the process of differentiation and enhance the output of insulin-producing cells and increase the amount of insulin-releasing, Dr Liu et al. transfected PDX-1 into primary pancreatic ductal epithelial cells and then differentiated the transfected cells into insulin-producing cells.

In contrast, the expression of PDX-1 and insulin mRNA and protein were detectable in the transfected cells. Endogenous PDX-1 might play an important role during differentiation and the transfected cells can produce more insulin-releasing cells and release more insulin after induction.

The results of this study suggest a promising future for many diabetic patients who need islets transplantation. Due to the high percentage of diabetes mellitus and severe complications around the world, this case reported by Dr. Liu et al. is surely worth the attention of the researchers of diabetes.

*Reference: Liu T, Wang CY, Yu F, Gou SM, Wu HS, Xiong JX, Zhou F. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells. World J Gastroenterol 2007; 13(39): 5232-5237


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "New Source Of Islet Cells For Islet Transplantion For Type 1 Diabetes." ScienceDaily. ScienceDaily, 25 October 2007. <www.sciencedaily.com/releases/2007/10/071025094932.htm>.
World Journal of Gastroenterology. (2007, October 25). New Source Of Islet Cells For Islet Transplantion For Type 1 Diabetes. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2007/10/071025094932.htm
World Journal of Gastroenterology. "New Source Of Islet Cells For Islet Transplantion For Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2007/10/071025094932.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins