Featured Research

from universities, journals, and other organizations

Cough Medicine Fights Dyskinesias In Parkinson's

Date:
November 9, 2007
Source:
Oregon Health & Science University
Summary:
A cough suppressant and a drug tested against schizophrenia curb dyskinesias, the involuntary movements that are disabling side effects of taking the Parkinson's disease medication levodopa, scientists found. Dextromethorphan, used in such cold and flu medications as Robitussin and Sucrets, suppresses dyskinesias in rats. BMY-14802, a drug tested in people with schizophrenia, also suppresses dyskinesias in rats, and does so more effectively than dextromethorphan, suggesting BMY-14802 might block dyskinesias in people with Parkinson's.

A cough suppressant and a drug tested as a schizophrenia therapy curb the involuntary movements that are disabling side effects of taking the Parkinson's disease medication levodopa, Portland scientists have found.

Dextromethorphan, used in such cold and flu medications as Robitussin, Sucrets, Triaminic and Vicks, suppresses dyskinesias in rats, researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center found. Dyskinesias are the spastic or repetitive motions that result from taking levodopa, or L-dopa, over long periods.

The researchers also found that BMY-14802, a drug previously tested in people with schizophrenia and found to be safe -- although not effective in treating schizophrenia symptoms -- suppressed dyskinesias in rats more effectively than dextromethorphan did, suggesting that BMY-14802 might work to block dyskinesias in people with Parkinson's.

"These results were unexpected, but very exciting," said the study's lead author, Melanie A. Paquette, Ph.D., postdoctoral fellow in the Department of Behavioral Neuroscience, OHSU School of Medicine, and the PVAMC. "We have filed a patent for the use of BMY-14802 for dyskinesias and we hope to get funding to begin human trials very soon."

The study, titled "Differential effects of NMDA antagonists and sigma ligands on L-dopa-induced behavior in the hemiparkinson rat," is being presented during a poster session today at Neuroscience 2007, the 37th annual Society for Neuroscience conference in San Diego.

The results also affirm the value of the rat model for dyskinesias that Paquette's team used in the study. Previous studies by other researchers have shown the drug amantadine already is effective in treating dyskinesias in both humans and rats, and dextromethorphan's effectiveness against the condition in rats provides more data supporting the use of the model.

"Basically, these two drugs work to block dyskinesias in both humans and rats, and that means the rats are a good model to screen potential drug treatments for humans with dyskinesias," Paquette said.

But BMY-14802, which is an antagonist at sigma-1 receptor sites in the brain, "worked much better than dextromethorphan," an antagonist at N-methyl-D-aspartate (NMDA) receptors.

"There's something special about BMY-14802," Paquette explained. "The effect on dyskinesias is really striking and I've repeated it several times, so it's a reliable finding. It's a very exciting result."

The study was funded by the National Institute on Drug Abuse and the National Institute of Neurological Disorders and Stroke, National Institutes of Health, and the U.S. Department of Veterans Affairs.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Cough Medicine Fights Dyskinesias In Parkinson's." ScienceDaily. ScienceDaily, 9 November 2007. <www.sciencedaily.com/releases/2007/11/071107160159.htm>.
Oregon Health & Science University. (2007, November 9). Cough Medicine Fights Dyskinesias In Parkinson's. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2007/11/071107160159.htm
Oregon Health & Science University. "Cough Medicine Fights Dyskinesias In Parkinson's." ScienceDaily. www.sciencedaily.com/releases/2007/11/071107160159.htm (accessed August 20, 2014).

Share This




More Mind & Brain News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com
Mental, Neurological Disabilities Up 21% Among Kids

Mental, Neurological Disabilities Up 21% Among Kids

Newsy (Aug. 18, 2014) New numbers show a decade's worth of changes in the number of kids with disabilities. They suggest mental disabilities are up; physical ones are down. Video provided by Newsy
Powered by NewsLook.com
Fake Weed Wreaks Havoc In New Hampshire

Fake Weed Wreaks Havoc In New Hampshire

Newsy (Aug. 17, 2014) New Hampshire's governor declared a state of emergency after more than 40 overdoses of synthetic marijuana in one week throughout the state. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins