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Cough Medicine Fights Dyskinesias In Parkinson's

Date:
November 9, 2007
Source:
Oregon Health & Science University
Summary:
A cough suppressant and a drug tested against schizophrenia curb dyskinesias, the involuntary movements that are disabling side effects of taking the Parkinson's disease medication levodopa, scientists found. Dextromethorphan, used in such cold and flu medications as Robitussin and Sucrets, suppresses dyskinesias in rats. BMY-14802, a drug tested in people with schizophrenia, also suppresses dyskinesias in rats, and does so more effectively than dextromethorphan, suggesting BMY-14802 might block dyskinesias in people with Parkinson's.

A cough suppressant and a drug tested as a schizophrenia therapy curb the involuntary movements that are disabling side effects of taking the Parkinson's disease medication levodopa, Portland scientists have found.

Dextromethorphan, used in such cold and flu medications as Robitussin, Sucrets, Triaminic and Vicks, suppresses dyskinesias in rats, researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center found. Dyskinesias are the spastic or repetitive motions that result from taking levodopa, or L-dopa, over long periods.

The researchers also found that BMY-14802, a drug previously tested in people with schizophrenia and found to be safe -- although not effective in treating schizophrenia symptoms -- suppressed dyskinesias in rats more effectively than dextromethorphan did, suggesting that BMY-14802 might work to block dyskinesias in people with Parkinson's.

"These results were unexpected, but very exciting," said the study's lead author, Melanie A. Paquette, Ph.D., postdoctoral fellow in the Department of Behavioral Neuroscience, OHSU School of Medicine, and the PVAMC. "We have filed a patent for the use of BMY-14802 for dyskinesias and we hope to get funding to begin human trials very soon."

The study, titled "Differential effects of NMDA antagonists and sigma ligands on L-dopa-induced behavior in the hemiparkinson rat," is being presented during a poster session today at Neuroscience 2007, the 37th annual Society for Neuroscience conference in San Diego.

The results also affirm the value of the rat model for dyskinesias that Paquette's team used in the study. Previous studies by other researchers have shown the drug amantadine already is effective in treating dyskinesias in both humans and rats, and dextromethorphan's effectiveness against the condition in rats provides more data supporting the use of the model.

"Basically, these two drugs work to block dyskinesias in both humans and rats, and that means the rats are a good model to screen potential drug treatments for humans with dyskinesias," Paquette said.

But BMY-14802, which is an antagonist at sigma-1 receptor sites in the brain, "worked much better than dextromethorphan," an antagonist at N-methyl-D-aspartate (NMDA) receptors.

"There's something special about BMY-14802," Paquette explained. "The effect on dyskinesias is really striking and I've repeated it several times, so it's a reliable finding. It's a very exciting result."

The study was funded by the National Institute on Drug Abuse and the National Institute of Neurological Disorders and Stroke, National Institutes of Health, and the U.S. Department of Veterans Affairs.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Cough Medicine Fights Dyskinesias In Parkinson's." ScienceDaily. ScienceDaily, 9 November 2007. <www.sciencedaily.com/releases/2007/11/071107160159.htm>.
Oregon Health & Science University. (2007, November 9). Cough Medicine Fights Dyskinesias In Parkinson's. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2007/11/071107160159.htm
Oregon Health & Science University. "Cough Medicine Fights Dyskinesias In Parkinson's." ScienceDaily. www.sciencedaily.com/releases/2007/11/071107160159.htm (accessed July 29, 2014).

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