Featured Research

from universities, journals, and other organizations

Two Proteins -- ABCA1 and ABCG1 -- combine to enable HDL to protect against cardiovascular disease

Date:
November 12, 2007
Source:
Journal of Clinical Investigation
Summary:
Individuals with an imbalance in the amount of cholesterol associated with the carrier complexes HDL and LDL have an increased risk of developing cardiovascular disease, a class of diseases that affect the heart and or blood vessels, including atherosclerosis. In this context, high levels of HDL protect against cardiovascular disease, but the mechanisms behind this protection are poorly understood.

Individuals with an imbalance in the amount of cholesterol associated with the carrier complexes HDL and LDL have an increased risk of developing cardiovascular disease, a class of diseases that affect the heart and or blood vessels, including atherosclerosis.

In this context, high levels of HDL protect against cardiovascular disease, but the mechanisms behind this protection are poorly understood.

New insight into the antiatherogenic effects of HDL is provided by a study in mice by Laurent Yvan-Charvet and colleagues at Columbia University New York.

HDL is known to promote the efflux of cholesterol from cells known as macrophage foam cells via two proteins known as ABCA1 and ABCG1.

Previous studies examining the role of each of these proteins individually have produced conflicting results as to the importance of this process for the antiatherogenic effects of HDL.

In this study, mice lacking both ABCA1 and ABCG1 were generated.

When bone marrow from these mice was transplanted into mice susceptible to developing atherosclerosis the recipients developed atherosclerosis more rapidly than recipients of normal bone marrow or bone marrow lacking either ABCA1 or ABCG1.

These data indicate that efflux of cholesterol via ABCA1 and ABCG1 is central to the antiatherogenic properties of HDL.

Article: Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice, Journal of Clinical Investigation, November 8, 2007


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Two Proteins -- ABCA1 and ABCG1 -- combine to enable HDL to protect against cardiovascular disease." ScienceDaily. ScienceDaily, 12 November 2007. <www.sciencedaily.com/releases/2007/11/071108175609.htm>.
Journal of Clinical Investigation. (2007, November 12). Two Proteins -- ABCA1 and ABCG1 -- combine to enable HDL to protect against cardiovascular disease. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2007/11/071108175609.htm
Journal of Clinical Investigation. "Two Proteins -- ABCA1 and ABCG1 -- combine to enable HDL to protect against cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2007/11/071108175609.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins