Featured Research

from universities, journals, and other organizations

Forteo's Bone-building Power Shown In Arthritis Patients

Date:
November 26, 2007
Source:
University of Alabama at Birmingham
Summary:
In a head-to-head comparison of the two drugs, Forteo increased lumbar spine density measurements by 7.2 percent compared to 3.4 percent for Fosamax, and it boosted hip density measurements by 3.8 percent compared to 2.4 percent for Fosamax. The study looked at changes in bone density over the course of 18 months in arthritis patients with prednisone-induced osteoporosis.

he osteoporosis drug Forteo works better than Fosamax to strengthen bones in arthritis patients with prednisone-induced osteoporosis, according to a new study from a researcher at the University of Alabama at Birmingham (UAB.)

Related Articles


In a head-to-head comparison of the two drugs, Forteo, part of a class of drugs called parathyroid hormones, more than doubled osteoporosis patients' bone density measurements and significantly reduced the risk of new spinal fractures when compared to those taking Fosamax.

Forteo increased lumbar spine density measurements by 7.2 percent compared to 3.4 percent for Fosamax, and it boosted hip density measurements by 3.8 percent compared to 2.4 percent for Fosamax, the UAB researcher said. The study looked at changes in bone density over the course of 18 months.

The findings are published in the Nov. 15 issue of the New England Journal of Medicine.

"Patients and their doctors need more bone-building options," said Kenneth Saag, M.D., M.Sc., a professor in the UAB Division of Clinical Immunology and Rheumatology and the study's lead author.

"Because having arthritis and being on medication for that disease is important. Reducing your risk of hip fracture or spinal compression is equally important," Saag said.

"This study significantly improves our understanding of treatment options for secondary osteoporosis, which is osteoporosis caused by taking glucocorticoid drugs like prednisone," he said.

Glucocorticoids like prednisone are widely used by arthritis patients and others to help reduce inflammation and shrink swollen tissues and joints. But these drugs can cause another problem -- an increased risk of bone loss, bone fracture and osteoporosis.

International guidelines currently recommend a class of drugs called bisphosphonates, which includes Fosamax, for patients diagnosed with and at risk for glucocorticoid-induced osteoporosis. Saag said many experts hope Forteo is part of the next wave of medicines that work to build back bone, reduce bone loss and minimize fracture risks in arthritis patients.

For the NEJM study, 428 adults with glucocorticoid-induced osteoporosis were chosen to receive either a once-daily Forteo injection or a once-daily Fosamax pill. Their spine and hip bone density measurements were taken at the start of the trial and at the end using a DEXA scan, a low-level X-ray machine that detects slight changes in bone density.

In addition to taking bone-density measurements, the study authors found the Forteo patients had higher levels of protein and biological markers of bone formation in their urine when compared to the Fosamax group.

The differences between Forteo and Fosamax in terms of serious side effects were not significant, Saag said. He and the study's co-authors conclude that because parathyroid hormone appears to trigger the growth of bone-forming cells called osteoblasts, Forteo may effectively counteract the negative effects of glucocorticoid use in bones. Fosamax works to counteract osteoporosis through a different cell pathway.

Currently Forteo is only approved for use in postmenopausal women with osteoporosis, and in certain cases for men with hormonal-linked osteoporosis. The drug maker Eli Lilly and Company is awaiting federal approval to have Forteo listed among approved medicines in patients with glucocorticoid-induced osteoporosis.


Story Source:

The above story is based on materials provided by University of Alabama at Birmingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Alabama at Birmingham. "Forteo's Bone-building Power Shown In Arthritis Patients." ScienceDaily. ScienceDaily, 26 November 2007. <www.sciencedaily.com/releases/2007/11/071114183257.htm>.
University of Alabama at Birmingham. (2007, November 26). Forteo's Bone-building Power Shown In Arthritis Patients. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/11/071114183257.htm
University of Alabama at Birmingham. "Forteo's Bone-building Power Shown In Arthritis Patients." ScienceDaily. www.sciencedaily.com/releases/2007/11/071114183257.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins