Featured Research

from universities, journals, and other organizations

Overexpression Of Human Protein Reduces Severity Of Alzheimer's Disease In Mice

Date:
November 19, 2007
Source:
Buck Institute for Age Research
Summary:
Mice genetically engineered to both overproduce the protein neuroglobin and to develop Alzheimer's disease (AD) had a much milder form of the disease when compared to mice engineered to have AD alone.

Mice genetically engineered to both overproduce the protein neuroglobin and to develop Alzheimer’s disease (AD) had a much milder form of the disease when compared to mice engineered to have AD alone, researchers at the Buck Institute for Age Research have reported.

Results of the study highlight continued efforts by Buck faculty member David Greenberg, MD, PhD and lead author Adil Khan, PhD, and colleagues to identify the body’s natural protective mechanisms with the ultimate goal of finding drugs that boost healing efforts in humans.

Neuroglobin, closely related to hemoglobin (the oxygen-carrying protein in blood), is expressed predominantly in the brain of vertebrate animals, including humans, but its normal function is unknown. In this study, the AD mice who overexpressed neuroglobin performed significantly better on a memory test and had less of the sticky deposits commonly associated with the neurodegenerative disease.

In earlier studies, an overexpression of neuroglobin was found to protect mice from nerve damage following stroke and to lessen damage from heart muscle following heart attacks. The results hold the promise that a drug could be developed to encourage the overproduction of neuroglobin in humans, providing the same protective effects.

“We are now screening existing drugs and chemical compounds to find those that prompt the body to produce more neuroglobin,” said Greenberg.

Joining Greenberg and Khan in the work include Buck Institute investigators, Kunlin Jin, Xiao Ou Mao, and Surita Banwait.

This research was published the week of November 12 in the on-line edition of the Proceedings of the National Academy of Sciences.

The work was funded by a grant from the National Institutes of Health.


Story Source:

The above story is based on materials provided by Buck Institute for Age Research. Note: Materials may be edited for content and length.


Cite This Page:

Buck Institute for Age Research. "Overexpression Of Human Protein Reduces Severity Of Alzheimer's Disease In Mice." ScienceDaily. ScienceDaily, 19 November 2007. <www.sciencedaily.com/releases/2007/11/071117210600.htm>.
Buck Institute for Age Research. (2007, November 19). Overexpression Of Human Protein Reduces Severity Of Alzheimer's Disease In Mice. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/11/071117210600.htm
Buck Institute for Age Research. "Overexpression Of Human Protein Reduces Severity Of Alzheimer's Disease In Mice." ScienceDaily. www.sciencedaily.com/releases/2007/11/071117210600.htm (accessed July 28, 2014).

Share This




More Mind & Brain News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins