Featured Research

from universities, journals, and other organizations

Enzyme Linked To Breast Cancer Malignancy

Date:
December 3, 2007
Source:
McGill University
Summary:
Researchers have uncovered the crucial role played by the enzyme focal adhesion kinase in the onset of breast cancer. Using transgenic mice with pre-existing cancers, the scientists were able to disable the function of FAK in the mammary gland.

McGill University researchers have uncovered the crucial role played by the enzyme focal adhesion kinase (FAK) in the onset of breast cancer.

Using transgenic mice with pre-existing cancers, the McGill team was able to disable the function of FAK in the mammary gland. "When we did that, we basically blocked tumour progression in our mouse model," said Dr. Muller, Professor of Biochemistry at McGill, Canada Research Chair in Molecular Oncology and a researcher with the Molecular Oncology Group at the McGill University Health Centre (MUHC). "This shows that FAK, which was already linked to tumour growth in skin carcinomas, is very critical for tumour progression from a pre-malignant to a malignant state in the mammary tumour system."

Dr. Muller and his team made a similar breakthrough with an earlier discovery in 2004, when they showed that the protein beta1-integrin was similarly critical in the initiation of tumour growth and development of breast cancer in genetically engineered mice.

Likewise, when this gene was blocked, cancerous tumours ceased to grow. The current discovery about FAK is an exciting sequel to the earlier research, says Dr. Muller, because, unlike beta1-integrin, kinase enzymes are eminently "druggable" with current technology.

Dr. Muller cautions that this study -- like the Beatson Institute's earlier research linking FAK to tumour progression in skin carcinomas -- is still preliminary. "However, developing an FAK inhibitor would certainly add another weapon to the arsenal for dealing with breast cancer," he said.

The research, led by Dr. William Muller -- along with colleagues from McGill and the Beatson Institute for Cancer Research in Scotland -- was published the week of November 26 in the Proceedings of the National Academy of Sciences (PNAS). The study's first author is Dr. Hicham Lahlou, a post-doctoral fellow in Dr. Muller's lab.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Cite This Page:

McGill University. "Enzyme Linked To Breast Cancer Malignancy." ScienceDaily. ScienceDaily, 3 December 2007. <www.sciencedaily.com/releases/2007/11/071129113755.htm>.
McGill University. (2007, December 3). Enzyme Linked To Breast Cancer Malignancy. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2007/11/071129113755.htm
McGill University. "Enzyme Linked To Breast Cancer Malignancy." ScienceDaily. www.sciencedaily.com/releases/2007/11/071129113755.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins