Featured Research

from universities, journals, and other organizations

Genetic Testing May Help People With Severe Type Of Migraine

Date:
December 4, 2007
Source:
American Academy of Neurology
Summary:
People with a severe type of migraine in which one side of the body becomes weak should consider genetic testing, according to research that has found familial genes for this type of migraine in people who did not have family members experiencing the problem. Screening for familial genes in people with this type of sporadic migraine may also help to enable counseling and prevent unnecessary treatment with potentially harmful drugs.

People with a severe type of migraine in which one side of the body becomes weak should consider genetic testing, according to research that has found familial genes for this type of migraine in people who did not have family members experiencing the problem.

"Our findings have important clinical implications," said study author Michel D. Ferrari, MD, PhD, with Leiden University Medical Centre in the Netherlands. "Since many people with this type of migraine are initially misdiagnosed and not given the proper treatment, understanding the genetic basis of this type of migraine may help clinicians in diagnosing and treating the problem. Most patients are initially diagnosed with epilepsy, stroke or other disorders and are treated accordingly with non-effective medications that are associated with a high risk of side effects rather than with effective agents to treat migraine."

For the study, genetic testing was performed on 39 men and women with sporadic hemiplegic migraine, which is a rare, often severe subtype of migraine with aura in which attacks are associated with a weakness affecting one side of the body. The participants, who had no known family members with this type of migraine, were screened for mutations in the three known genes for familial hemiplegic migraine: the CACNA1A gene, the ATPIA2 gene, and the SCN1A gene.

The study found variants of these familial genes in 18 percent of the study participants. Variants in the ATPIA2 gene were the most prevalent.

Ferrari says screening for familial genes in people with this type of sporadic migraine may also help to enable counseling and prevent unnecessary treatment with potentially harmful drugs.

"Our findings reinforce the growing evidence that familial and sporadic hemiplegic migraine along with normal migraine have some shared gene pathways. Unraveling these pathways may help to identify new treatment options," said Ferrari.

The findings are published in the December 4, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

The study was supported by grants from the Netherlands Organization for Scientific Research, the Migraine Trust, EUROHEAD, and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Genetic Testing May Help People With Severe Type Of Migraine." ScienceDaily. ScienceDaily, 4 December 2007. <www.sciencedaily.com/releases/2007/12/071203164814.htm>.
American Academy of Neurology. (2007, December 4). Genetic Testing May Help People With Severe Type Of Migraine. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2007/12/071203164814.htm
American Academy of Neurology. "Genetic Testing May Help People With Severe Type Of Migraine." ScienceDaily. www.sciencedaily.com/releases/2007/12/071203164814.htm (accessed September 18, 2014).

Share This



More Mind & Brain News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) — Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) — The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) — A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) — In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins