Featured Research

from universities, journals, and other organizations

New Drug Can Restore Social Ability In Schizophrenics

Date:
December 8, 2007
Source:
Göteborg University
Summary:
The social behavior of rats displaying schizophrenic tendencies is restored when they are treated with two new potential drugs that seem to have unique effects on dopaminergic signaling. Schizophrenia is a severe psychiatric disorder with symptoms that include hallucinations and delusions. Other common effects are social withdrawal, lack of initiative, dulled emotions, and difficulty in experiencing pleasure.

The social behaviour of rats displaying schizophrenic tendencies is restored when they are treated with two new potential drugs that seem to have unique effects on dopaminergic signalling. This is a conclusion of a thesis from the Sahlgrenska Academy.

Schizophrenia is a severe psychiatric disorder with symptoms that include hallucinations and delusions. Other common effects are social withdrawal, lack of initiative, dulled emotions, and difficulty in experiencing pleasure.

“The treatment available for schizophrenic patients hardly ever relieves impairment of social function. If patients are to have satisfactory lives, we must find new drugs,” says pharmacologist Johan Rung, who has studied the two drug candidates, OSU6162 and ACR16.

In the studies, rats were given a type of drug known for inducing a schizophrenia-like state in humans, and this reduced the rats’ social behaviour. When the rats were given the two drug candidates, normal social behaviour was restored.

“This indicates that the two drugs can relieve the schizophrenic’s lack of ability to interact socially, and also have positive effects on a number of other symptoms thought to be caused by the same underlying mechanisms,” says Johan Rung.

In contrast to other drugs that only reduce dopaminergic signalling in the brain, the two new substances seem to be able to both reduce and strengthen the signalling, depending on the circumstances.

“This is a property that can be particularly beneficial in the treatment of schizophrenia. Different groups of symptoms can be linked to either elevated or reduced dopaminergic signalling in different parts of the brain,” says Johan Rung.

More years of research lie ahead before doctors can prescribe the new substances as drugs for their patients. An international drug company has recently started to test ACR16 on patients. The other substance, OSU6162, has also been tested on a small number of schizophrenia patients, and the results are promising.

Schizophrenia

Schizophrenia is a psychiatric disease that afflicts one percent of the population. There is no cure, but psychotic symptoms can be treated with psychopharmaceuticals. The onset usually occurs when people are in their twenties. The condition is often severe, and most patients never return to school or work.


Story Source:

The above story is based on materials provided by Göteborg University. Note: Materials may be edited for content and length.


Cite This Page:

Göteborg University. "New Drug Can Restore Social Ability In Schizophrenics." ScienceDaily. ScienceDaily, 8 December 2007. <www.sciencedaily.com/releases/2007/12/071206225858.htm>.
Göteborg University. (2007, December 8). New Drug Can Restore Social Ability In Schizophrenics. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/12/071206225858.htm
Göteborg University. "New Drug Can Restore Social Ability In Schizophrenics." ScienceDaily. www.sciencedaily.com/releases/2007/12/071206225858.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) — New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) — Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) — Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) — A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins