Featured Research

from universities, journals, and other organizations

Oncology: The Long And Winding Trail To Cancer

Date:
December 15, 2007
Source:
Journal of Clinical Investigation
Summary:
Two new mouse studies have provided insight into the role of the death-inducing protein TRAIL and its receptors in tumor development and metastasis. Binding of TRAIL to its receptors induces the cells expressing the receptors to undergo a form of cell death known as apoptosis. Scientists found that if lymphoma-prone mice were deficient in the TRAIL receptor they developed lymphoma more frequently than TRAIL receptor--sufficient lymphoma-prone mice.

Two new mouse studies have provided insight into the role of the death-inducing protein TRAIL and its receptors in tumor development and metastasis.

Related Articles


Binding of TRAIL to its receptors induces the cells expressing the receptors to undergo a form of cell death known as apoptosis. Wafik El-Deiry and colleagues from the University of Pennsylvania, Philadelphia, found that if lymphoma-prone mice were deficient in the TRAIL receptor they developed lymphoma more frequently than TRAIL receptor--sufficient lymphoma-prone mice. In addition, the lymphoma was more likely to metastasize.

Consistent with these effects in lymphoma-prone mice, normal mice deficient in the TRAIL receptor developed more irradiation-induced lung tumors and more chemical-induced liver tumors than normal TRAIL-sufficient mice.

Further analysis showed a role for the TRAIL receptor in controlling chronic inflammation, leading the authors to suggest that the TRAIL receptor functions as a suppressor of inflammation and tumor development in multiple tissues.

Using a multistage model of squamous cell skin cancer, a team of researchers from the German Cancer Research Center, Heidelberg, and the Fred Hutchinson Cancer Research Center, Seattle, found a role for the TRAIL receptor in tumor metastasis but not primary tumor development.

TRAIL receptor--deficient mice treated with a chemical on the skin, developed tumors at the same rate, and tumors of the same size, as normal mice. However, the skin tumors in the TRAIL receptor--deficient mice metastasized to the lymph nodes more frequently, leading the authors to suggest that agonists of the human receptors for TRAIL might reduce the incidence of metastasis.

Journal article: TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. Journal of Clinical Investigation. January, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Oncology: The Long And Winding Trail To Cancer." ScienceDaily. ScienceDaily, 15 December 2007. <www.sciencedaily.com/releases/2007/12/071214201334.htm>.
Journal of Clinical Investigation. (2007, December 15). Oncology: The Long And Winding Trail To Cancer. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/12/071214201334.htm
Journal of Clinical Investigation. "Oncology: The Long And Winding Trail To Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/12/071214201334.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins