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Perfusion In Burn Injuries Rapidly Determined By Using Improved Laser-Doppler Technology, Hospital Test Shows

Date:
December 17, 2007
Source:
University of Twente
Summary:
The perfusion of a burn injury can now rapidly be determined by using a new technique. Using the perfusion image made by a laser and an ultra fast camera, doctors will be able to determine whether a burn needs surgery. Tests in hospital show that the system is perfectly capable of measuring differences in perfusion in burn wounds; patients and medical staff speak positively about the high speed of the system and the quality of the images.

Perfusion images of the back of a hand, after application of Capsaicin crθme (Midalgan). This is a selection of a series of images recorded over a 15 minutes interval, in time steps of 45 seconds. Such a sequence of images cannot be realised with the old method using a scanning laser beam.
Credit: Image courtesy of University of Twente

The perfusion of a burn injury can now rapidly be determined by using a new technique developed by scientists of the University of Twente. Using the perfusion image made by a laser and an ultra fast camera, doctors will be able to determine whether a burn needs surgery. The new measuring device, developed under supervision of Dr. Wiendelt Steenbergen of the Biophysical Engineering group, has been successfully tested at the hospital Martini Ziekenhuis in Groningen.

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Tests in hospital show that the system is perfectly capable of measuring differences in perfusion in burn wounds; patients and medical staff are positive about the high speed of the system and the quality of the images.

A burn that shows good perfusion, has a better chance of healing by itself: no surgery is needed. In many cases, the visual inspection is not sufficient to take a decision on the necessity of surgery. This can lead to unnecessary surgery or, on the other hand, to unwanted delays when surgery is the best option.

Compared to current perfusion measurements, the new technique is much faster. Scanning techniques take minutes of time for some square centimeters of skin, during which time the patient is not allowed to move. The new technique will be capable of imaging an entire surface of ten by ten centimeter in a fraction of a second.

Doppler effect

In order to reach this high speed, the entire surface is lit at once using a wide laser beam. A high speed camera, capable of taking 27000 shots per second, takes images of the tissue. Whenever laser light is scattered by moving rood blood cells, this is visible in the intensity of the pixels; due to the Doppler effect, a colour shift will be visible. From the resulting ‘movie’ of the tissue, a perfusion image can be made.

Apart from this promising application in determing perfusion in burn injuries, Wiendelt Steenbergen predicts other applications, for example in evaluating the uptake of medication through the skin, or in testing allergic reactions. In evaluating diabetic micro circulation problems, the new technique could be an attractively fast alternative to current approaches as well.

Patent

Current market leader in Laser-Doppler equipment for perfusion imaging, Perimed AB from Sweden, has shown interest in the new technique. The Swedish company has signed a contract with Dutch Technology Foundation STW, for acquiring the patent on the technique. STW finances Steenbergen’s work.

The research has been done within the Biophysical Engineering Group of the University of Twente, which is part of the BMTI Institute for Biomedical Technology.


Story Source:

The above story is based on materials provided by University of Twente. Note: Materials may be edited for content and length.


Cite This Page:

University of Twente. "Perfusion In Burn Injuries Rapidly Determined By Using Improved Laser-Doppler Technology, Hospital Test Shows." ScienceDaily. ScienceDaily, 17 December 2007. <www.sciencedaily.com/releases/2007/12/071216130313.htm>.
University of Twente. (2007, December 17). Perfusion In Burn Injuries Rapidly Determined By Using Improved Laser-Doppler Technology, Hospital Test Shows. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2007/12/071216130313.htm
University of Twente. "Perfusion In Burn Injuries Rapidly Determined By Using Improved Laser-Doppler Technology, Hospital Test Shows." ScienceDaily. www.sciencedaily.com/releases/2007/12/071216130313.htm (accessed October 26, 2014).

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