Featured Research

from universities, journals, and other organizations

Researchers Reverse Effects Of Sleep Deprivation

Date:
January 3, 2008
Source:
Wake Forest University Baptist Medical Center
Summary:
Researchers have shown that the effects of sleep deprivation on cognitive performance can be reversed when the naturally occurring brain peptide, orexin-A, is administered in monkeys.

The effects of sleep deprivation on cognitive performance can be reversed when the naturally occurring brain peptide, orexin-A, is administered in monkeys, researchers have found.
Credit: iStockphoto/Neal McClimon

Researchers at Wake Forest University School of Medicine have shown that the effects of sleep deprivation on cognitive performance can be reversed when the naturally occurring brain peptide, orexin-A, is administered in monkeys.

"These findings are significant because of their potential applicability," said Samuel A. Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest. "This could benefit patients suffering from narcolepsy and other serious sleep disorders. But it also has applicability to shift workers, the military and many other occupations where sleep is often limited, yet cognitive demand remains high."

Orexin-A, also known as hypocretin-1, is a naturally occurring peptide produced in the brain that regulates sleep. It's secreted by a small number of neurons but affects many brain regions during the day and people who have normal amounts of orexin-A are able to maintain wakefulness. When people or animals are sleep-deprived, the brain attempts to produce more orexin-A, but often without enough success to achieve alertness past the normal day-night cycle.

The research team, consisting of Linda Porrino, Ph.D., and Robert Hampson, Ph.D, also of Wake Forest, and Jerome Siegel, Ph.D., of the University of California at Los Angeles, studied the effects of orexin-A on monkeys that were kept awake overnight for 30 to 36 hours with videos, music, treats and interaction with technicians, until their normal testing time the next day. They were then allowed to perform their trained tasks with several cognitive problems that varied in difficulty, and their performance was significantly impaired.

However, if the sleep deprived monkeys were administered orexin-A either intravenously or via a nasal spray immediately prior to testing, their cognitive skills improved to the normal, non-sleep-deprived, level. The researchers also noted that when the monkeys received the orexin-A via the intranasal spray they tested higher than when it was administered intravenously.

"Assessments of the monkeys' brain activity during testing through noninvasive imaging techniques also showed improvement by orexin-A which returned to its normal non-sleep-deprived pattern during performance of the task," said Deadwyler. "In addition, we observed that orexin-A at moderate dose levels had no effect on performance if the animals were not sleep-deprived."

Full results are published in the Journal of Neuroscience.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Researchers Reverse Effects Of Sleep Deprivation." ScienceDaily. ScienceDaily, 3 January 2008. <www.sciencedaily.com/releases/2008/01/080102093936.htm>.
Wake Forest University Baptist Medical Center. (2008, January 3). Researchers Reverse Effects Of Sleep Deprivation. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/01/080102093936.htm
Wake Forest University Baptist Medical Center. "Researchers Reverse Effects Of Sleep Deprivation." ScienceDaily. www.sciencedaily.com/releases/2008/01/080102093936.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins