Featured Research

from universities, journals, and other organizations

Overcoming Metabolic Syndrome

Date:
January 14, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. Individuals with a genetic predisposition to high cholesterol can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1, which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome.

Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes.

Individuals with a genetic predisposition to high cholesterol (familial hyperlipidemia or FH) can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1 (SCD1), which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome.

Previous mouse studies on SCD1 found that blocking this enzyme could reduce obesity in normal mice; Michael Hayden and colleagues wondered whether such a protective effect would extend to mice with excess cholesterol levels.

They mimicked FH in mice by knocking out the LDL receptor, causing a cholesterol buildup. When fed a high-fat Western diet, these mice develop obesity and diabetes in adulthood. However, when the researchers also knocked out SCD1, the mice improved dramatically, accumulating far less fat in their liver, which in turn led to fewer triglycerides in the blood, increased insulin sensitivity, and less weight gain.

These results highlight that SCD1 might be a potential drug target for FH individuals who have developed other components of metabolic syndrome


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Overcoming Metabolic Syndrome." ScienceDaily. ScienceDaily, 14 January 2008. <www.sciencedaily.com/releases/2008/01/080110144820.htm>.
American Society for Biochemistry and Molecular Biology. (2008, January 14). Overcoming Metabolic Syndrome. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2008/01/080110144820.htm
American Society for Biochemistry and Molecular Biology. "Overcoming Metabolic Syndrome." ScienceDaily. www.sciencedaily.com/releases/2008/01/080110144820.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins