Featured Research

from universities, journals, and other organizations

Alendronate Can Help Prevent Bone Fractures In Many Postmenopausal Women

Date:
January 25, 2008
Source:
Wiley-Blackwell
Summary:
Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, reducing their risk of fractures, a Cochrane Review has found. This finding applies to women who have started to lose their bone mass but have no fractures (primary prevention), as well as those who have lost significant bone mass and/or have had fractures (secondary prevention).

Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, reducing their risk of fractures, a Cochrane Review has found. This finding applies to women who have started to lose their bone mass but have no fractures (primary prevention), as well as those who have lost significant bone mass and/or have had fractures (secondary prevention).

Related Articles


Healthy bones constantly break down and rebuild their structure. The process is sensitive to hormones and once women have passed through the menopause the balance is disturbed; their bones tend to break down slightly more than they build. Over time this leads to a noticeable loss of bone mass, and weakening of the bones. Once the bones become too weak they are prone to fracture.

A team of Cochrane Researchers set out to evaluate the evidence behind the use of alendronate for primary and secondary prevention of bone fractures in these women. Alendronate works by inhibiting the bone break down process.

By studying the outcomes of eleven trials that involved a total of 12,068 women the researchers found significant evidence of both primary and secondary prevention against breaking bones in the back (vertebrae). In secondary prevention, there was also a statistically significant protection against fractures of other bones including those in the hip and wrist.

"This work revealed no increase in side effects in the women who were using the drugs, despite the fact that some studies outside clinical trials raise the possibility of stomach and jaw complaints," says lead author Dr George Wells, who works in the Department of Epidemiology and Community Medicine at the University of Ottawa.

"As a woman gets older, her risk of having on-going health problems or dying is significantly greater if she has reduced bone density and then breaks a bone such as a hip, so it is important to find effective preventative therapies with low or no side-effects," says Wells.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Alendronate Can Help Prevent Bone Fractures In Many Postmenopausal Women." ScienceDaily. ScienceDaily, 25 January 2008. <www.sciencedaily.com/releases/2008/01/080122203154.htm>.
Wiley-Blackwell. (2008, January 25). Alendronate Can Help Prevent Bone Fractures In Many Postmenopausal Women. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/01/080122203154.htm
Wiley-Blackwell. "Alendronate Can Help Prevent Bone Fractures In Many Postmenopausal Women." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122203154.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins