Mental And Physical Exercise Delays Dementia In Fatal Genetic Disease

This Australian research opens up new therapeutic possibilities for other devastating and difficult to treat brain diseases, including Alzheimer's disease where dementia is a key component.

The Florey's Dr Jess Nithianantharajah and Dr Anthony Hannan showed mice with the Huntington's disease gene displayed impairments on learning and memory tests at an early stage of the disease, prior to the obvious signs of movement problems. This closely correlates with observations in Huntington's disease patients.

However, Dr Jess Nithianantharajah said by providing the mice with an enriched environment that enhanced their mental and physical stimulation, the mice performed better on these memory tests.

"This discovery is quite remarkable because we have shown that an enriched environment not only delayed the onset of dementia, but it also slowed the progression of memory loss in these mice," Dr Jess Nithianantharajah said.

"We also showed that in the Huntington's disease mice, specific molecular changes occur that relate to communication between brain cells (synapses) in a region of the brain called the hippocampus, which plays a significant role in the formation of memories.

"The Huntington's disease mice without increased mental and physical activity showed decreased levels of specific proteins that are expressed at the synapse, which are essential for normal brain function.

"But the Huntington's disease mice exposed to increased mental and physical activity did not show this decrease," she said.

Huntington's is a very powerful model for nature-versus-nurture investigations. This discovery implies that gene-environment interactions and how they affect changes in the brain's pathways is important for all brain diseases.

Treatments for complex psychiatric disorders, like depression and schizophrenia, may also benefit from these research efforts.

This research was recently published in the international Journal of Neurobiology of Disease and involved collaborations between the Howard Florey Institute and the University of Melbourne.

Huntington's disease is an inherited disease that affects specific areas of the brain. It is caused by a mutation in a single gene and is inherited by 50 percent of the offspring of patients. A common symptom is the jerky movement of the arms and legs, known as 'chorea', but patients also have difficulties with concentration and memory, as well as psychiatric symptoms such as depression. These symptoms gradually become more severe over the years, inevitably leading to death.