Featured Research

from universities, journals, and other organizations

Mouse Model Shows The Role Of Cell Signaling In Growth Of Cervical Cancer

Date:
January 30, 2008
Source:
Public Library of Science
Summary:
Cervical cancer is one of the most prevalent cancers in women worldwide and is the leading cause of cancer death for women in developing countries. Scientists investigate how cell signaling in the stroma -- the tissue that surrounds a tumor -- plays a role in the progression of cervical cancer.

Cervical cancer is one of the most prevalent cancers in women worldwide and is the leading cause of cancer death for women in developing countries. In new research Douglas Hanahan (University of California San Francisco, USA) and colleagues investigate how cell signaling in the stroma -- the tissue that surrounds a tumor -- plays a role in the progression of cervical cancer.

Using a mouse model of cervical cancer, the researchers looked at a protein that is made by the tumor cells known as platelet-derived growth factor (PDGF). The research finds that the signaling in the stromal cells triggered by the release of this protein stimulates the growth of the tumor.

In a separate perspective article, Rakesh Jain (Harvard Medical School, USA) and colleagues, who were not involved in the study, suggest that the results offer a "foundation for development of new approaches to the treatment of cervical cancer" that target PDGF signaling to slow the progression of the disease.

Citation: Pietras K, Pahler J, Bergers G, Hanahan D (2008) Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 5(1): e19. http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050019


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Mouse Model Shows The Role Of Cell Signaling In Growth Of Cervical Cancer." ScienceDaily. ScienceDaily, 30 January 2008. <www.sciencedaily.com/releases/2008/01/080129125517.htm>.
Public Library of Science. (2008, January 30). Mouse Model Shows The Role Of Cell Signaling In Growth Of Cervical Cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/01/080129125517.htm
Public Library of Science. "Mouse Model Shows The Role Of Cell Signaling In Growth Of Cervical Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/01/080129125517.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins