Featured Research

from universities, journals, and other organizations

Potential Cause Of Age Differences In Stimulant Response Identified

Date:
January 30, 2008
Source:
Temple University
Summary:
In young children, psycho-stimulants relieve symptoms of attention deficit disorder, yet in adolescents and adults, those same medications can cause euphoria and are often abused. What is behind these differing drug responses?

In young children, psychostimulants relieve symptoms of Attention Deficit Disorder, yet in adolescents and adults, those same medications can cause euphoria and are often abused.

What is behind these differing drug responses?

Temple University scientists have identified a potential molecular mechanism, the neurotrophin system comprised of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, as the cause of age differences in stimulant response. Their findings appear in the current issue of the Journal of Neuroscience.

"Our findings suggest that the rapidly developing young brain is able to adapt and protect itself against the rewarding effects of stimulants due to the input of the TrkB system," said Ellen Unterwald, PhD, lead investigator and professor of pharmacology at Temple University's School of Medicine and Center for Substance Abuse Research.

Most preclinical studies have found that susceptibility to the addictive properties of stimulants is age-dependent. This is the first study to link the TrkB neurotrophin system to those age-specific responses. The hope is that BDNF/TrkB might someday be used as a target for the development of new treatments for childhood neuropsychiatric disorders or addiction.

Unterwald and her research team specialize in the effects of drug use, abuse and withdrawal and are currently investigating neurobiological mechanisms involved in drug addiction.

Other authors on this study are Michelle Niculescu,1 Shane A. Perrine,1 Jonathan S. Miller,1 Michelle E. Ehrlich,2 1Deparment of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, 2Farber Institute for Neurosciences and Department of Neurology, Thomas Jefferson University College of Medicine, and 3Laboratory of the Biology of Addictive Diseases, The Rockefeller University.

The author wishes to acknowledge the input of her collaborator on this project, Michelle Ehrlich, MD, currently at Mt. Sinai School of Medicine.

This work was supported in part by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by Temple University. Note: Materials may be edited for content and length.


Cite This Page:

Temple University. "Potential Cause Of Age Differences In Stimulant Response Identified." ScienceDaily. ScienceDaily, 30 January 2008. <www.sciencedaily.com/releases/2008/01/080129175104.htm>.
Temple University. (2008, January 30). Potential Cause Of Age Differences In Stimulant Response Identified. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2008/01/080129175104.htm
Temple University. "Potential Cause Of Age Differences In Stimulant Response Identified." ScienceDaily. www.sciencedaily.com/releases/2008/01/080129175104.htm (accessed August 22, 2014).

Share This




More Mind & Brain News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins