Featured Research

from universities, journals, and other organizations

Epilepsy Drug Doesn't Help Prevent Migraine After All, New Research Shows

Date:
February 14, 2008
Source:
American Academy of Neurology
Summary:
Contrary to some reports, the epilepsy drug oxcarbazepine does not appear to prevent migraine, according to new research in Neurology. Researchers found no difference between the oxcarbazepine and placebo groups in the change in the number of migraine attacks from the beginning to the end of the study.

Contrary to some reports, the epilepsy drug oxcarbazepine does not appear to prevent migraine, according to research published in the February 12, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

Related Articles


The nearly five-month study involved 170 men and women at clinics across the United States with half of the group receiving a daily dose of oxcarbazepine; the other half took placebo. Both groups included people who had three to nine migraine attacks within a month.

Researchers found no difference between the oxcarbazepine and placebo groups in the change in the number of migraine attacks from the beginning to the end of the study.

"The results of this trial do not support preliminary data which had suggested oxcarbazepine was effective in preventing migraine," said study author Stephen D. Silberstein, MD, with Thomas Jefferson University in Philadelphia, and Fellow of the American Academy of Neurology. "While several epilepsy drugs have been used for decades to prevent migraine, oxcarbazepine did not prevent migraine in this study despite it being shown to be safe and well-tolerated."

Silberstein says the three epilepsy drugs that most effectively prevent migraine, topiramate, divalproex and gabapentin, have several mechanisms by which they treat migraine, including the ability to regulate a neurotransmitter known as GABA. In contrast, oxcarbazepine has no apparent activity on GABA. Silberstein says it's possible that epilepsy drugs must be able to regulate this neurotransmitter in order to prevent migraine.

In addition, Silberstein says several factors may have contributed to the lack of response in this study, including that the participants had difficult-to-treat migraines.

Migraine is estimated to affect more than 28 million Americans at some point in their lives, costing $18 billion per year in absenteeism and impaired work function and $1 billion dollars per year in medical care costs.

The study was supported by Novartis Pharmaceuticals Corporation, maker of oxcarbazepine.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Epilepsy Drug Doesn't Help Prevent Migraine After All, New Research Shows." ScienceDaily. ScienceDaily, 14 February 2008. <www.sciencedaily.com/releases/2008/02/080211172647.htm>.
American Academy of Neurology. (2008, February 14). Epilepsy Drug Doesn't Help Prevent Migraine After All, New Research Shows. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2008/02/080211172647.htm
American Academy of Neurology. "Epilepsy Drug Doesn't Help Prevent Migraine After All, New Research Shows." ScienceDaily. www.sciencedaily.com/releases/2008/02/080211172647.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins