Featured Research

from universities, journals, and other organizations

HPV-positive Head And Neck Cancer Patients Fare Better Than HPV-negative Patients

Date:
February 12, 2008
Source:
Journal of the National Cancer Institute
Summary:
Head and neck cancer patients with HPV-positive tumors tend to survive longer and are more responsive to treatment compared with patients with HPV-negative tumors, according to a new study.

Head and neck cancer patients with HPV-positive tumors tend to survive longer and are more responsive to treatment compared with patients with HPV-negative tumors, according to a study.

Related Articles


Human papillomavirus has been shown to be involved in the development of some head and neck cancers, particularly cancers of the upper throat, or oropharynx. Retrospective studies suggest that patients with HPV-positive tumors generally have a better prognosis than those patients with HPV-negative tumors, but these findings must be confirmed in clinical trials.

To examine the association between HPV infection and cancer prognosis, Maura Gillison, M.D., Ph.D., of Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University in Baltimore and colleagues followed 96 patients with stage III or IV cancer of the oropharynx or larynx (voicebox). All of the patients were enrolled in the same phase II clinical trial and received the same treatment. The researchers collected data on the patients' response to treatment and their survival times, as well as whether their tumors were HPV-positive or -negative.

Patients with HPV-positive tumors had higher response rates after chemoradiation therapy, compared to patients with HPV-negative tumors (84 percent vs. 57 percent), and their two-year overall survival rates were also higher (95 percent vs. 62 percent).

"Our data suggest that the risks and benefits of...therapies should be considered separately for HPV-positive and -negative patients," the authors write.

Citation: Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML. Improved Survival of Patients With Human Papillomavirus -- Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial. J Natl Cancer Inst 2008;100: 261 -- 269


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "HPV-positive Head And Neck Cancer Patients Fare Better Than HPV-negative Patients." ScienceDaily. ScienceDaily, 12 February 2008. <www.sciencedaily.com/releases/2008/02/080212165433.htm>.
Journal of the National Cancer Institute. (2008, February 12). HPV-positive Head And Neck Cancer Patients Fare Better Than HPV-negative Patients. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/02/080212165433.htm
Journal of the National Cancer Institute. "HPV-positive Head And Neck Cancer Patients Fare Better Than HPV-negative Patients." ScienceDaily. www.sciencedaily.com/releases/2008/02/080212165433.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins