Featured Research

from universities, journals, and other organizations

Intensive Insulin Therapy May Be Harmful To The Critically Ill, Study Suggests

Date:
March 3, 2008
Source:
BioMed Central/Critical Care
Summary:
Doubt has been cast over the current practice of administering intensive insulin therapy to all critically ill patients, according to a new study. In certain groups of patients it could even be harmful.

Doubt has been cast over the current practice of administering intensive insulin therapy to all critically ill patients, according to a study published this week in the open access journal Critical Care. In certain groups of patients it could even be harmful.

This therapy is used widely in hospitals around the world, yet only one randomised, controlled trial showing unequivocal benefit has been published -- and this trial focused mainly on patients who had undergone cardiac surgery. So, a team from Harborview Medical Center and the University of Washington, Seattle, set out to explore the relationship between intensive insulin therapy and hospital mortality in a mixed population of critically ill patients.

The researchers examined the outcomes of all (10,456) patients admitted to the seven intensive care units (ICUs) of Harborview Medical Center, the only Level 1 trauma center in a 5 state area of the northwest USA, before and after the introduction of intensive insulin protocols.

The study period (March 2001 to February 2005) was split into three consecutive sections: Period I (no specific glycemic control protocol), Period II (target glucose 80--130mg/dL) and Period III (target glucose 80--110mg/dL). The study population included a mix of trauma, surgical, neurosurgical and medical ICU patients.

They found that a policy of intensive insulin therapy was not associated with a decrease in hospital mortality. While the proportion of patients receiving insulin infusions increased from 9% in Period I to 42% in Period III, patients in Period III tended towards higher hospital mortality than those in Period I. Hospital mortality was increased in patients with an ICU stay of three days or less.

The authors suggest that further study is necessary before intensive insulin therapy is implemented widely in critically ill patients.

They write: "We observed that intensive insulin therapy in a mixed cohort of critically ill patients was not associated with a reduction in hospital mortality, and was associated with increased ICU and hospital mortality in some subgroups. "These results, combined with data from the most recently concluded randomised trials, suggest that broad implementation of intensive insulin therapy may be premature, and that additional randomised trials in diverse groups of critically ill patients are necessary."

Journal reference: Intensive Insulin Therapy and Mortality in Critically Ill Patients. Miriam M Treggiari, Veena Karir, N D Yanez, Noel S Weiss, Stephen Daniel and Steven Deem. Critical Care (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Critical Care. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Critical Care. "Intensive Insulin Therapy May Be Harmful To The Critically Ill, Study Suggests." ScienceDaily. ScienceDaily, 3 March 2008. <www.sciencedaily.com/releases/2008/02/080228213731.htm>.
BioMed Central/Critical Care. (2008, March 3). Intensive Insulin Therapy May Be Harmful To The Critically Ill, Study Suggests. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2008/02/080228213731.htm
BioMed Central/Critical Care. "Intensive Insulin Therapy May Be Harmful To The Critically Ill, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/02/080228213731.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins