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'Female Sex Hormone' Protects Against Hearing Loss In Females And Males

Date:
March 5, 2008
Source:
Journal of Clinical Investigation
Summary:
The "female sex hormone" estradiol is present in both men and women. It plays various roles in addition to its gender-specific ones, including having effects on the hearing (auditory) system. In a new study, mice deficient in the estrogen receptor beta exhibited reduced recovery from auditory trauma, and treatment with ER beta-binding drugs protected mice from auditory damage, leading to the suggestion that these data might enable the development of new treatments for hearing loss.

The "female sex hormone" estradiol is present in both men and women, and is generated from testosterone in men by the protein aromatase.

Estradiol plays various roles in addition to its gender-specific ones, including having effects on the hearing (auditory) system.

In a new study, Barbara Canlon and colleagues at the Karolinska Institute in Stockholm, Sweden, investigated the role of estradiol-binding proteins, known as estrogen receptors, in response to auditory damage by examining hearing loss recovery in mice with deficiencies in various estrogen receptors.

They found that mice deficient in only the estrogen receptor ER-beta had reduced recovery from auditory trauma, and that treatment with ER-beta binding drugs protected mice from auditory damage.

Furthermore, not only was ER-beta found in the ears of both male and female mice, but levels of the nerve-protecting protein BDNF were reduced in mice that lacked either ER-beta or aromatase.

The authors therefore concluded that this identification of an auditory-protective role for the estrogen receptor ER-beta may enable the development of new treatments for hearing loss.

The journal article is entitled Estrogen receptor beta protects against acoustic trauma in mice.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "'Female Sex Hormone' Protects Against Hearing Loss In Females And Males." ScienceDaily. ScienceDaily, 5 March 2008. <www.sciencedaily.com/releases/2008/03/080303190640.htm>.
Journal of Clinical Investigation. (2008, March 5). 'Female Sex Hormone' Protects Against Hearing Loss In Females And Males. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/03/080303190640.htm
Journal of Clinical Investigation. "'Female Sex Hormone' Protects Against Hearing Loss In Females And Males." ScienceDaily. www.sciencedaily.com/releases/2008/03/080303190640.htm (accessed October 21, 2014).

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