Featured Research

from universities, journals, and other organizations

Lymphoma Patients Benefit From Combined PET-CT Scanning, Study Suggests

Date:
March 15, 2008
Source:
University of Southern California
Summary:
Combined positron emission tomography and computed tomography imaging of lymphoma patients is a more effective method to evaluate response to radiation therapy, and may help patients avoid unnecessary follow-up treatments, a new study suggests. The fused imaging results in greater accuracy when evaluating treatment results.

Combined positron emission tomography (PET) and computed tomography (CT) imaging of lymphoma patients is a more effective method to evaluate response to radiation therapy, and may help patients avoid unnecessary follow-up treatments, a study by researchers at the University of Southern California (USC) suggests.

The clinical study is the first to show the advantage of combined PET-CT imaging in evaluating radioimmunotherapy for patients with non-Hodgkin lymphoma, says Gary Ulaner, M.D., Ph.D., radiology resident and nuclear medicine fellow at the Keck School of Medicine of USC and the principal investigator of the study.

"Combined PET-CT imaging is more accurate in defining a complete response to radio-immunotherapy treatment," Ulaner says. "Specifically, PET-CT is able to correctly label inactive scar masses, which are sometimes mistaken for active cancer when CT is used alone."

Radioimmunotherapy is a type of radiation treatment that targets cancer cells through antibodies. The therapy causes less harm to healthy cells and usually results in fewer side effects than other cancer treatments, Ulaner notes. Typically, the treatment has been evaluated by use of CT imaging alone, which uses special x-ray equipment to produce multiple images of the inside of the body.

PET is a type of nuclear medicine imaging that uses very small amounts of radioactive material to diagnose or treat disease and other abnormalities. When PET and CT scans are combined they can produce a more complete image of the cancer metabolism, he says.

Researchers from the USC Positron Emission Tomography Center evaluated five men and five women--ranging in age from 38 to 70 years--who underwent PET and CT imaging both several weeks before and several months after radioimmunotherapy for non-Hodgkin lymphoma. After evaluation of CT images alone, eight of ten patients were classified as responders to treatment, and two patients were classified as having a complete response to the treatment.

After reevaluating with the fused PET-CT scans, researchers found that two patients who had residual lesions had been misclassified. Both of the patients were free of evident disease, and remained healthy after 18 or more months of follow up.

"Using this relatively novel hybrid imaging means that some patients will only require a one-day treatment of radioimmunotherapy instead of several rounds of chemotherapy," says Peter Conti, M.D, Ph.D., professor of radiology at the Keck School of Medicine. "We will have a more accurate image that will identify the patients who have a complete response to the treatment."

Conti is a national leader in treatment of non-Hodgkin lymphoma with radioimmunotherapy. "We hope this research will result in PET-CT imaging becoming the standard for evaluating patients after treatment," he says. "Greater accuracy will improve how physicians care for lymphoma patients."

Journal reference: Gary A. Ulaner, Patrick M. Colletti and Peter S. Conti. "B-Cell Non-Hodgkin Lymphoma: PET/CT Evaluation after Y-Ibritumomab Tiuxetan Radioimmunotheray--Initial Experience." Radiology (2008). 10.1148/radiol.2463060588


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University of Southern California. "Lymphoma Patients Benefit From Combined PET-CT Scanning, Study Suggests." ScienceDaily. ScienceDaily, 15 March 2008. <www.sciencedaily.com/releases/2008/03/080312092829.htm>.
University of Southern California. (2008, March 15). Lymphoma Patients Benefit From Combined PET-CT Scanning, Study Suggests. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2008/03/080312092829.htm
University of Southern California. "Lymphoma Patients Benefit From Combined PET-CT Scanning, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/03/080312092829.htm (accessed August 27, 2014).

Share This




More Matter & Energy News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Australian Airlines Relax Phone Ban Too

Australian Airlines Relax Phone Ban Too

Reuters - Business Video Online (Aug. 26, 2014) Qantas and Virgin say passengers can use their smartphones and tablets throughout flights after a regulator relaxed a ban on electronic devices during take-off and landing. As Hayley Platt reports the move comes as the two domestic rivals are expected to post annual net losses later this week. Video provided by Reuters
Powered by NewsLook.com
Hurricane Marie Brings Big Waves to California Coast

Hurricane Marie Brings Big Waves to California Coast

Reuters - US Online Video (Aug. 26, 2014) Huge waves generated by Hurricane Marie hit the Southern California coast. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Chinese Researchers Might Be Creating Supersonic Submarine

Chinese Researchers Might Be Creating Supersonic Submarine

Newsy (Aug. 26, 2014) Chinese researchers have expanded on Cold War-era tech and are closer to building a submarine that could reach the speed of sound. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: India Coal Strained by Supreme Court Ruling

Breakingviews: India Coal Strained by Supreme Court Ruling

Reuters - Business Video Online (Aug. 26, 2014) An acute coal shortage is likely to be aggravated as India's supreme court declared government coal allocations illegal, says Breakingviews' Peter Thal Larsen. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins