Featured Research

from universities, journals, and other organizations

Controlling Your Appetite Requires PI3K Signaling

Date:
April 1, 2008
Source:
Journal of Clinical Investigation
Summary:
How much we want to eat, in other words our appetite, and how much energy we burn, are both controlled by a hormone known as leptin. Leptin is made by fat tissue and it passes through the circulation to the brain, where it modifies the activity of several types of nerve cell, including POMC nerves, to signal to the body that it does not need to eat more and that it needs to burn more energy.

How much we want to eat, in other words our appetite, and how much energy we burn, are both controlled by a hormone known as leptin. Leptin is made by fat tissue and it passes through the circulation to the brain, where it modifies the activity of several types of nerve cell, including POMC nerves, to signal to the body that it does not need to eat more and that it needs to burn more energy.

As obesity can be caused if leptin-mediated signaling goes awry, much effort is being expended trying to identify the signaling pathways activated by leptin. Joel Elmquist and colleagues, at the University of Texas Southwestern Medical Center, Dallas, have provided new insight into the signaling pathways by which leptin mediates its effects on POMC nerves in mice.

In the study, analysis of the brain tissue of normal mice indicated that leptin caused rapid activation of POMC nerves. These effects of leptin could be blocked by inhibitors of a signaling molecule known as PI3K and mice with genetically disrupted PI3K signaling in POMC cells failed to activate the nerve cells in response to leptin.

Furthermore, targeted disruption of PI3K interfered with leptin-induced suppression of feeding. Despite these short-term consequences, the absence of POMC PI3K signaling had no detectable impact on long-term regulation of body weight, leading the authors to propose that POMC PI3K signaling is essential for suppressing appetite, but that PI3K signaling in POMC neurons is not the primary signaling pathway by which leptin regulates long-term energy expenditure.

Journal reference: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. Journal of Clinical Investigation. April 1, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Controlling Your Appetite Requires PI3K Signaling." ScienceDaily. ScienceDaily, 1 April 2008. <www.sciencedaily.com/releases/2008/04/080401184915.htm>.
Journal of Clinical Investigation. (2008, April 1). Controlling Your Appetite Requires PI3K Signaling. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2008/04/080401184915.htm
Journal of Clinical Investigation. "Controlling Your Appetite Requires PI3K Signaling." ScienceDaily. www.sciencedaily.com/releases/2008/04/080401184915.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins