Featured Research

from universities, journals, and other organizations

Controlling Your Appetite Requires PI3K Signaling

Date:
April 1, 2008
Source:
Journal of Clinical Investigation
Summary:
How much we want to eat, in other words our appetite, and how much energy we burn, are both controlled by a hormone known as leptin. Leptin is made by fat tissue and it passes through the circulation to the brain, where it modifies the activity of several types of nerve cell, including POMC nerves, to signal to the body that it does not need to eat more and that it needs to burn more energy.

How much we want to eat, in other words our appetite, and how much energy we burn, are both controlled by a hormone known as leptin. Leptin is made by fat tissue and it passes through the circulation to the brain, where it modifies the activity of several types of nerve cell, including POMC nerves, to signal to the body that it does not need to eat more and that it needs to burn more energy.

Related Articles


As obesity can be caused if leptin-mediated signaling goes awry, much effort is being expended trying to identify the signaling pathways activated by leptin. Joel Elmquist and colleagues, at the University of Texas Southwestern Medical Center, Dallas, have provided new insight into the signaling pathways by which leptin mediates its effects on POMC nerves in mice.

In the study, analysis of the brain tissue of normal mice indicated that leptin caused rapid activation of POMC nerves. These effects of leptin could be blocked by inhibitors of a signaling molecule known as PI3K and mice with genetically disrupted PI3K signaling in POMC cells failed to activate the nerve cells in response to leptin.

Furthermore, targeted disruption of PI3K interfered with leptin-induced suppression of feeding. Despite these short-term consequences, the absence of POMC PI3K signaling had no detectable impact on long-term regulation of body weight, leading the authors to propose that POMC PI3K signaling is essential for suppressing appetite, but that PI3K signaling in POMC neurons is not the primary signaling pathway by which leptin regulates long-term energy expenditure.

Journal reference: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. Journal of Clinical Investigation. April 1, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Controlling Your Appetite Requires PI3K Signaling." ScienceDaily. ScienceDaily, 1 April 2008. <www.sciencedaily.com/releases/2008/04/080401184915.htm>.
Journal of Clinical Investigation. (2008, April 1). Controlling Your Appetite Requires PI3K Signaling. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2008/04/080401184915.htm
Journal of Clinical Investigation. "Controlling Your Appetite Requires PI3K Signaling." ScienceDaily. www.sciencedaily.com/releases/2008/04/080401184915.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins