Featured Research

from universities, journals, and other organizations

Maltreatment During Childhood Associated With Combination Of Inflammation And Depression In Adults

Date:
April 10, 2008
Source:
JAMA and Archives Journals
Summary:
A history of neglect or abuse in childhood appears to be associated with depression and inflammation in adulthood, a combination that may increase cardiovascular risk.

A history of neglect or abuse in childhood appears to be associated with depression and inflammation in adulthood, a combination that may increase cardiovascular risk, according to a new report.

"Major depression is a multisystemic disorder that affects both brain and bodily functions," the authors write as background information in the article. Depression and cardiovascular disease often occur simultaneously, and inflammation (chronic activation of the immune system) has been linked to both. "However, not all individuals with depression have elevated levels of inflammation. Those who do could be at highest risk for cardiovascular disease."

Andrea Danese, M.D., M.Sc., of King's College London, and colleagues studied 1,000 New Zealand residents born between 1972 and 1973. Assessments were carried out every two years between ages 3 and 15, then again at ages 18, 21, 26 and 32. Childhood maltreatment--including rejection by a child's mother, harsh discipline, physical or sexual abuse or disruptive changes in caregivers--was identified through parental reports during childhood years, objective observations of behavior and participants' own reports once they reached adulthood. At age 32, participants underwent physical examinations as well as clinical interviews to diagnose depression.

Individuals with current depression and a history of childhood maltreatment were more likely to have a high level of inflammation at age 32, as measured by the presence of the chemical high-sensitivity C-reactive protein in the blood. Those with depression but no history of childhood maltreatment did not have this increased risk. "The elevated inflammation levels in individuals who were both depressed and maltreated were not explained by correlated risk factors such as depression recurrence, low socioeconomic status in childhood or adulthood, poor health or smoking," the authors write.

"Information about experiences of childhood maltreatment may help to identify depressed individuals with elevated inflammation levels and, thus, greater risk of cardiovascular disease," the authors conclude. "In turn, the early recognition of the health risk associated with maltreatment history might help to address pressing needs for the care of depressed individuals such as the reduction of the effect of depression on comorbid [co-occurring] medical illness."

Journal reference: Arch Gen Psychiatry. 2008;65[4]:409-416.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Maltreatment During Childhood Associated With Combination Of Inflammation And Depression In Adults." ScienceDaily. ScienceDaily, 10 April 2008. <www.sciencedaily.com/releases/2008/04/080407160740.htm>.
JAMA and Archives Journals. (2008, April 10). Maltreatment During Childhood Associated With Combination Of Inflammation And Depression In Adults. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/04/080407160740.htm
JAMA and Archives Journals. "Maltreatment During Childhood Associated With Combination Of Inflammation And Depression In Adults." ScienceDaily. www.sciencedaily.com/releases/2008/04/080407160740.htm (accessed July 28, 2014).

Share This




More Mind & Brain News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins