Featured Research

from universities, journals, and other organizations

Folic Acid Supplementation Provided In Utero, But Not After Birth, May Protect Offspring From Colorectal Cancer

Date:
April 16, 2008
Source:
American Association for Cancer Research
Summary:
Although folic acid fortification has proven to lower rates of neural tube defects and some childhood cancers, there is a growing body of evidence that too much folic acid may increase one's risk of developing colorectal cancer. A new study suggests that folic acid supplementation provided in utero, but not postnatally, may protect offspring from developing colorectal cancer.

Although folic acid fortification has proven to lower rates of neural tube defects and some childhood cancers, there is a growing body of evidence that too much folic acid may increase one's risk of developing colorectal cancer. A new study suggests that folic acid supplementation provided in utero, but not postnatally, may protect offspring from developing colorectal cancer.

"This study provides important insights into the critical role of timing of folic acid intervention in colorectal cancer development and progression. Folic acid may prevent 'new' cancers in the colorectum," said Karen K. Sie, a graduate medical student at the University of Toronto.

The University of Toronto research team had previously demonstrated that folic acid supplementation could promote the progression of the earliest precursor to colorectal cancer. This study focused on whether or not folic acid supplementation in utero could reduce the risk of colorectal cancer in the offspring.

Researchers placed female rats on a control diet or folic acid supplemented diet three weeks prior to breeding, and they stayed on this diet throughout pregnancy and lactation. The male pups from each group were then fed a control or folic acid supplemented diet at weaning.

At five to six weeks, the pups were injected with a colorectal cancer causing chemical, and, at 34 weeks, researchers measured tumor incidence, multiplicity and burden as well as plasma folate, homocysteine and liver folate concentrations.

Pups from mothers on the control diet had a nearly three-fold increased risk of developing colorectal cancer compared with those from rats on folic acid supplementation. Maternal folic acid supplementation significantly decreased the risk of offspring developing colorectal cancer while postnatal folic acid supplementation had no significant effect on the incidence of tumor development.

"Even though folic acid has been successful in reducing neural tube defect rates and is beneficial against some childhood cancers, the potential long term benefits and adverse effects of the drastically increased folate status in the North American population needs to be closely monitored," said Sie. "With the continuing debate and controversy surrounding mandatory folic acid fortification and supplementation, it is critical to determine safe and effective doses and timing of folic acid intervention for colorectal cancer prevention."

This research was presented at the American Association for Cancer Research 2008 Annual Meeting, April 12-16.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Folic Acid Supplementation Provided In Utero, But Not After Birth, May Protect Offspring From Colorectal Cancer." ScienceDaily. ScienceDaily, 16 April 2008. <www.sciencedaily.com/releases/2008/04/080413183000.htm>.
American Association for Cancer Research. (2008, April 16). Folic Acid Supplementation Provided In Utero, But Not After Birth, May Protect Offspring From Colorectal Cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/04/080413183000.htm
American Association for Cancer Research. "Folic Acid Supplementation Provided In Utero, But Not After Birth, May Protect Offspring From Colorectal Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/04/080413183000.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins