Featured Research

from universities, journals, and other organizations

Anesthesia And Alzheimer's Disease

Date:
April 25, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein.

In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein.

Over 200 million people undergo surgery each year, and there has been concern that anesthetic use may contribute to Alzheimer's and other brain disorders. Bin Zhang, Yuanlin Dong, Rudolph Tanzi, Zhongcong Xie, and colleagues examined this possibility with commonly used inhalation anesthetics isoflurane previously and desflurane more recently.

They subjected human brain cells to 12% desflurane for six hours (mimicking a surgery condition) and observed no changes in either the production of amyloid-beta protein or the rate of cell death. However, when combined with low oxygen levels (18%), desflurane could stimulate these cellular changes associated with Alzheimer's (hypoxia by itself did not induce any changes). The results with desflurane are contrary to the researchers' previous work, which found isoflurane by itself could stimulate both amyloid production and cell death.

The researchers do emphasize that the current findings are from cell culture experiments, and the next critical step will be to confirm these findings in animal models and test the effects of other anesthetic agents. But, these early results suggest that it is important to ensure anesthetic patients maintain sufficient oxygen in their brain.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Anesthesia And Alzheimer's Disease." ScienceDaily. ScienceDaily, 25 April 2008. <www.sciencedaily.com/releases/2008/04/080425123402.htm>.
American Society for Biochemistry and Molecular Biology. (2008, April 25). Anesthesia And Alzheimer's Disease. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2008/04/080425123402.htm
American Society for Biochemistry and Molecular Biology. "Anesthesia And Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2008/04/080425123402.htm (accessed August 21, 2014).

Share This




More Mind & Brain News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) — Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) — Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) — A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins