Featured Research

from universities, journals, and other organizations

Anesthesia And Alzheimer's Disease

Date:
April 25, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein.

In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein.

Over 200 million people undergo surgery each year, and there has been concern that anesthetic use may contribute to Alzheimer's and other brain disorders. Bin Zhang, Yuanlin Dong, Rudolph Tanzi, Zhongcong Xie, and colleagues examined this possibility with commonly used inhalation anesthetics isoflurane previously and desflurane more recently.

They subjected human brain cells to 12% desflurane for six hours (mimicking a surgery condition) and observed no changes in either the production of amyloid-beta protein or the rate of cell death. However, when combined with low oxygen levels (18%), desflurane could stimulate these cellular changes associated with Alzheimer's (hypoxia by itself did not induce any changes). The results with desflurane are contrary to the researchers' previous work, which found isoflurane by itself could stimulate both amyloid production and cell death.

The researchers do emphasize that the current findings are from cell culture experiments, and the next critical step will be to confirm these findings in animal models and test the effects of other anesthetic agents. But, these early results suggest that it is important to ensure anesthetic patients maintain sufficient oxygen in their brain.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Anesthesia And Alzheimer's Disease." ScienceDaily. ScienceDaily, 25 April 2008. <www.sciencedaily.com/releases/2008/04/080425123402.htm>.
American Society for Biochemistry and Molecular Biology. (2008, April 25). Anesthesia And Alzheimer's Disease. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/04/080425123402.htm
American Society for Biochemistry and Molecular Biology. "Anesthesia And Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2008/04/080425123402.htm (accessed July 24, 2014).

Share This




More Mind & Brain News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins