Featured Research

from universities, journals, and other organizations

Japanese Mushroom Leads To Breakthrough In Protein Research

Date:
May 3, 2008
Source:
Utrecht University
Summary:
Using an enzyme of the Japanese mushroom Grifola frondosa (Maitake or dancing mushroom), proteins can be identified without knowing the organism's genetic composition. This advance simplifies the study of proteins lying at the root of such diseases as cancer and diabetes.

Maitake mushrooms. Using an enzyme of the Japanese mushroom Grifola frondosa (Maitake or dancing mushroom), proteins can be identified without knowing the organism's genetic composition.
Credit: iStockphoto/Laryn Bakker

Using an enzyme of the Japanese mushroom Grifola frondosa (Maitake or dancing mushroom), proteins can be identified without knowing the organism's genetic composition. This advance simplifies the study of proteins lying at the root of such diseases as cancer and diabetes. Utrecht University Prof. Albert Heck's research group announced this breakthrough on the website of the journal Nature Methods.

Proteins play a critical role in disease and growth processes of humans, animals and plants. Identification was previously only possible when the genetic composition of the organism in question was known. Thanks to Heck's discovery, this is now a thing of the past. Heck used an enzyme from the Japanese mushroom Grifola frondosa to identify proteins.

This makes it possible to study the proteins of an organism of which the genetic composition is – as yet – unknown (e.g. exotic animal species). In addition, research into proteins responsible for such diseases as cancer and diabetes, which usually undergo modification as a result, is much more effective.

Protein cleaving

In order to study the role proteins play in biological processes, the proteins themselves are cleaved into peptides, which are analysed using a mass spectrometer. The measurements produce a unique ‘fingerprint’ for each peptide. In the past, a protein could only be identified using the fingerprint after comparing the fingerprint to a database of known genetic compositions.

The enzyme of the Japanese mushroom that Heck used cleaved the proteins in such a way that the peptides produced simplified fingerprints. As a result, the proteins could be identified even though the organism's genome has not been mapped out. This greatly simplifies protein identification.


Story Source:

The above story is based on materials provided by Utrecht University. Note: Materials may be edited for content and length.


Cite This Page:

Utrecht University. "Japanese Mushroom Leads To Breakthrough In Protein Research." ScienceDaily. ScienceDaily, 3 May 2008. <www.sciencedaily.com/releases/2008/04/080430124524.htm>.
Utrecht University. (2008, May 3). Japanese Mushroom Leads To Breakthrough In Protein Research. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/04/080430124524.htm
Utrecht University. "Japanese Mushroom Leads To Breakthrough In Protein Research." ScienceDaily. www.sciencedaily.com/releases/2008/04/080430124524.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Washed-Up 'Alien Hairballs' Are Actually Algae

Washed-Up 'Alien Hairballs' Are Actually Algae

Newsy (Sep. 22, 2014) Green balls of algae washed up on Sydney, Australia's Dee Why Beach. Video provided by Newsy
Powered by NewsLook.com
Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins