Featured Research

from universities, journals, and other organizations

Not All Cells Respond The Same Way To Insulin

Date:
May 5, 2008
Source:
Journal of Clinical Investigation
Summary:
One of the characteristic features of the disease type 2 diabetes is the inability of cells of the body to respond to the hormone insulin, something known as insulin resistance. One of the effects of insulin resistance, high levels of glucose circulating in the blood, was more pronounced in the mice in which the receptor for insulin was eliminated in all cells of the body than in the mice in which the receptor for insulin was only eliminated in the cells outside the brain.

One of the characteristic features of the disease type 2 diabetes is the inability of cells of the body to respond to the hormone insulin, something known as insulin resistance.

To determine whether resistance to the effects of insulin on cells in the brain or on cells outside the brain is important for disease, Jens Brόning and colleagues at the University of Cologne, Germany, engineered mice such that when they were given a drug the receptor for insulin was eliminated in either all the cells of the body or only the cells outside the brain.

It was observed that one of the effects of insulin resistance, high levels of glucose circulating in the blood, was more pronounced in the mice in which the receptor for insulin was eliminated in all cells of the body than in the mice in which the receptor for insulin was only eliminated in the cells outside the brain.

The mice lacking the receptor for insulin in all their cells also had less of the white type of fat tissue. Consistent with this, injection of insulin into the brain of normal mice increased the mass of white fat tissue and the size of white fat cells. These data indicate that the cells of the brain mediate some effects in response to insulin that are not mediated by cells outside the brain when they detect the same hormone.

Journal reference: Central insulin action regulates peripheral glucose and fat metabolism in mice. Journal of Clinical Investigation. May 1, 2008.

 


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Not All Cells Respond The Same Way To Insulin." ScienceDaily. ScienceDaily, 5 May 2008. <www.sciencedaily.com/releases/2008/05/080501180314.htm>.
Journal of Clinical Investigation. (2008, May 5). Not All Cells Respond The Same Way To Insulin. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2008/05/080501180314.htm
Journal of Clinical Investigation. "Not All Cells Respond The Same Way To Insulin." ScienceDaily. www.sciencedaily.com/releases/2008/05/080501180314.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins